In this study, optimizations were carried out for a heater core and an evaporator installed in a passenger car. The main geometric parameters of each component were selected as design variables, and the main performances examined were the outlet temperature and the pressure drop. In addition, the sensitivity analysis was performed to grasp the dominant design variable. The thermal flow analysis for each component was performed using the commercial program STAR CCM+. On the other hand, EasyDesign, a commercial program based on DOE and metamodel-based optimization, was used as an optimization tool. The optimized performances of the heater core were compared with performance target, and finally, the improved designs of the heater and the evaporator were presented.