As the designated name, adenocarcinoma, not otherwise specific (ANOS) revealed lack of histomorphologic characteristics that could classify the tumors under specific name. ANOS had nothing in common with other salivary gland malignancies, but glandular differentiation. The purpose of this study is to find out the solid characteristics of ANOS on the base of cytological and architectural features. 20 ANOS cases were studied. We identified 20 patients with salivary adenocarcinoma, not otherwise specified, ranging in age from 26 to 76 years (median, 53.85 years), with slight female predilection (female 11: male 9). The minor salivary gland was the most common site of tumor origin, especially on the palatal area (11 out of 20). The size of tumor was from 1.0 to 7.0(median 3.07). For the histopathological analysis, we classified the tumors by cytological and architecture patterns. Basaloid and epitheloid cytological patterns were showed with solid, microcystic/pseudocystic architecture. We found invasive growth patterns in 7 out of 20 cases. Reviewing and classifying the common features of ANOS could be helpful to make a diagnosis of malignant salivary gland tumors.

The germline stem cells of the Drosophila ovary continuously produce eggs throughout the life- span. Intricate regulation of stemness and differentiation is critical to this continuous production. The translational regulator Nos is an intrinsic factor that is required for maintenance of stemness in germline stem cells. Nos expression is reduced in differentiating cells at the post-transcriptional level by diverse translational regulators. However, molecular mechanisms underlying Nos repression are not completely understood. Through three distinct protein-protein interaction experiments, we identified specific molecular interactions between translational regulators involved in Nos repression. Our findings suggest a model in which protein complexes assemble on the 3’ untranslated region of Nos mRNA in order to regulate Nos expression at the posttranscriptional level.