International Atomic Energy Agency defines the term “Poison” as a substance used to reduce reactivity, by virtue of its high neutron absorption cross-section, in IAEA glossary. Poison material is generally used in the reactor core, but it is also used in dry storage systems to maintain the subcriticality of spent fuel. Most neutron poison materials for dry storage systems are boron-based materials such as Al-B Carbide Cermet (e.g., Boral®), Al-B Carbide MMC (e.g., METAMIC), Borated Stainless Steel, Borated Al alloy. These materials help maintain subcriticality as a part of the basket. U.S.NRC report NUREG-2214 provides a general assessment of aging mechanisms that may impair the ability of SSCs of dry storage systems to perform their safety functions during longterm storage periods. Boron depletion is an aging mechanism of neutron poison evaluated in that report. Although that report concludes that boron depletion is not considered to be a credible aging mechanism, the report says analysis of boron depletion is needed in original design bases for providing long-term safety of DSS. Therefore, this study aimed to simulate the composition change of neutron poison material in the KORAD-21 system during cooling time considering spent fuel that can be stored. The neutron source term of spent fuel was calculated by ORIGEN-ARP. Using that source term, neutron transport calculation for counting neutrons that reach neutron poison material was carried out by MCNP®-6.2. Then, the composition change of neutron poison material by neutron-induced reaction was simulated by FISPACT-II. The boron-10 concentration change of neutron poison material was analyzed at the end. This study is expected to be the preliminary study for the aging analysis of neutron poison material about boron depletion.