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        검색결과 3

        1.
        2014.06 KCI 등재 구독 인증기관 무료, 개인회원 유료
        Candelilla wax-in-water nanoemulsions stabilized by Span 80/Tween 80 were prepared by the phase inversion composition (PIC) method. Stable nanoemulsions with droplet diameters below 50 nm could be formed when the hydrophilic–lipophilic balance (HLB) values were between 13.5 and 14.5, surfactant concentration was 5.0 wt%, and the surfactant-wax ratio was 1:1. Increased emulsification temperature and cooling rate were found to improve the emulsion properties. Process of PIC (adding aqueous phase to the wax phase) produced smaller droplet size nanoemulsion compared to the process of adding wax phase to the aqueous phase. The stability of these nanoemulsions was assessed by following the change in droplet diameters with time of storage at room temperature (∼25 °C). The size remained constant during 2 months storage time.
        4,000원
        2.
        2013.12 KCI 등재 구독 인증기관 무료, 개인회원 유료
        We have investigated the influence of system composition and preparation conditions on the particle size of vitamin E acetate (VE)-loaded nanoemulsions prepared by PIC(phase inversion composition) emulsification. This method relies on the formation of very fine oil droplets when water is added to oil/surfactant mixture. The oil-to-emulsion ratio content was kept constant (5 wt.%) while the surfactant-to-oil ratio (%SOR) was varied from 50 to 200 %. Oil phase composition (vitamin E to medium chain ester ratio, %VOR) had an effect on particle size, with the smallest droplets being formed below 60 % of VOR. Food-grade non-ionic surfactants (Tween 80 and Span 80) were used as an emulsifier. The effect of f on the droplet size distribution has been studied. In our system, the droplet volume fraction, given by the oil volume fraction plus the surfactant volume fraction, was varied from 0.1 to 0.3. The droplet diameter remains less than 350 nm when O/S is fixed at 1:1. The droplet size increases gradually as the increasing the volume fraction. Particle size could also be reduced by increasing the temperature when water was added to oil/ surfactant mixture. By optimizing system composition and homogenization conditions we were able to form VE-loaded nanoemulsions with small mean droplet diameters (d < 50 nm). The PIC emulsification method therefore has great potential for forming nanoemulsion-based delivery systems for food, personal care, and pharmaceutical applications.
        4,000원
        3.
        2014.06 KCI 등재 서비스 종료(열람 제한)
        물/Span 80-Tween 80/긴 사슬 파라핀 오일 계에서 PIC (조성 상전이) 방법을 이용하여 O/W 나노에멀젼을 제조하였다. 제조 온도를 30 ℃에서 80 ℃로 상승시킴에 따라 제조된 나노에멀젼의 입경은 120 nm에서 40 nm로 감소하여 나노에멀젼을 형성하였다. 혼합 계면활성제의 HLB를 변화시킴에 따라 12.0 ~ 13.0 부근에서 가장 작은 입경을 형성하는 최적 HLB가 존재하였다. 나노에멀젼의 점도는 액적의 부피 분율(ϕ)에 따라 현격하게 증가하였으나, 입경의 크기는 약간 증가하였다. 그리고, ϕ ≤ 0.3 조건에서 나노에멀젼의 크기 분포는 2 개월 이상 일정하게 유지 되었다. 이러한 결과는 점성 파라핀 오일의 경우 30 ℃에서는 PIC 방식으로 거의 분산 할 수 없음을 보여주지만, 제조 온도가 증가할 경우 단 분산 나노에멀젼의 제조가 가능하다는 것을 보여준다. 나노에멀젼이 생성되면, Ostwald ripening에 대한 안정성은 연속 상에서 액상 파라핀 오일의 매우 낮은 용해도로 인해 안정하게 되며, 이는 화장품 응용에서 매우 중요하다.