In nuclear power plant (NPP) decommissioning, ventilation and purification of the building atmosphere are important to create a working environment, ensure worker safety, and prevent the release of gaseous radioactive materials into the environment. The heating, ventilation, and air conditioning (HVAC) system of each building is maintained, modified, or newly installed. In this study, based on APR1400, operation strategies were presented in case of ventilation abnormalities in the reactor containment building (RCB), where highly radioactive particles and high dust are most frequently generated during NPP decommissioning. For research, it was assumed that the entire RCB atmospheric ventilation during decommissioning would use the RCB purge system of the existing NPP and perform continuous ventilation. Additionally, it is assumed that areas where high radiation particles and high dust occur locally, such as reactor containers or internal segments, are sealed with tents and purified using a HEFA filter of a temporary portable HVAC, and a exhaust flow path is connected to the discharge duct of the existing RCB purge system. The possibility of abnormal occurrence was largely divided into two cases. First, when large amounts of uncontrolled pollutants are released into the atmosphere inside the RCB, discharge to the environment is stopped manually or automatically by a modified engineered safety function activation signal (ESFAS). Afterwards, the RCB purge system should be operated in recirculation mode to sufficiently purify the RCB atmosphere with a HEPA filter. Second, when the first train of the low volume purge system is not running due to a failure, standby train should be operated. If both low volume purge trains fail, a high volume purge system is used. Intermittent purge operation is preferred due to large capacity during high volume purge operation. In cases where it is not possible to operate all purge systems due to common issues such as power supply, atmospheric sampling is performed to determine whether to proceed with the work inside RCB.