In this study, we analyzed the structural safety and vibration characteristics of rotational drive in 3D CT scan equipment using finite element analysis. The analysis results showed a safety factor of 9.2 and a left and right vertical deflectional deviation of 0.24mm from the maximum equivalent stress. After applying weight compensation of 27.7kgf, the structural analysis reduced the safety factor to 7.6, but the deflectional deviation of the left and right structure was reduced to 0mm. Also, we presented the optimum design of rotational drive through the vibration analysis.