Recently, volatile organic compound(VOC) has been noted as a main cause of air pollution. VOC, with its toxic and offensive odor, is hazardous to health. Furthermore indoor, underground and high-rise buildings are preferable living spaces. People spend more than 80% of the day indoor, so indoor air pollution is a matter of importance. In Korea, from 2004, 10 types of indoor pollutants in public facilities have been identified. However, there is no standard for individual VOC, so the regulation has not yet effectively been carried out. In this study, we have studied on the diffusion of Benzene in a room using a numerical analysis for various air-controlled conditions consisted of door, window and ventilation system. This study investigates spatial concentration distribution and time-history of room-averaged benzene concentration for several cases. The results of this study show that when the room is ventilated by a small fan only for 30 minutes, the average concentration of benzene is decreased a very little, thus the impact to human body would be serious compared to the case of natural ventilation by window and door. In the case of natural ventilation by window and door, if the wind speed is higher than 0.5m/s, it takes small than 4 minutes for benzene to spread to the target concentration of 1.2mg/㎥.