This study investigated the smoke blocking and control systems for the safety of residents evacuation and for the prevention of smoke spread through the central corridor in the event of central corridor type of intelligent building fire. We offered additional ways of utilizing smoke ventilators and intake ventilation equipment and utilized CFD-based fire simulation program(FDS Ver.5.5.3) in order to analyze the effect. As a result, many differences in the smoke block effect, depending on the application of smoke ventilator and location of installation, was found. In addition, the result was found that larger effect was showed not in the case of application of smoke ventilator in central corridor only but application in fire room. The reason is that the smoke leakage is blocked primarily as air is flowed in the fire room through open door by operation of intake smoke ventilator in the public corridor and secondarily, the smoke leakage to the public corridor could be blocked as fire and smoke were released to the opened smoke ventilator continuously. Especially, the effect was maximized through complex interactions by applying smoke ventilator and intake ventilation equipment in corridor together rather than applying smoke ventilator and intake ventilation equipment independently. The proposed measure through this study shall be considered from architectural plan as one of ways for blocking from smoke spread to the central corridor in the central corridor type of intelligent building. In addition, flaws on regulation shall be established and supplemented.