This study analyzed the effect of workers' socio-psychological burden factors on musculoskeletal disorders. A survey was conducted targeting office and field workers in the Seoul metropolitan area. Analysis was performed using the results of 357 surveys out of 400 surveys. The analysis results were derived as follows. First, the socio-psychological burden factor did not show statistically significant results for musculoskeletal disorders. Second, it was found that job stress factors also had a positive effect on musculoskeletal disorders. Third, social psychological burden factors were found to be more positive than office workers than field workers. Fourth, there was a statistically significant correlation between job stress and musculoskeletal disease risk scores. From the above results, job stress factors affect musculoskeletal disease risk factors (work frequency, pain level, and duration) and the increase in musculoskeletal disorders and the number of accidents.