A synthesis of Dimer acid was studied from a tall oil fatty acid. Catalytic activity measured as reactant conversion in a autoclave reactor increase in accordance with the acidity. The optimization of process conditions were tested by an experimental design method. Optimization synthetic conditions of dimer acid and were reaction of tall oil fatty acid during 2 hour at 250℃, used of 7.3 wt% active clay and 1.2~1.4wt% water, and found reation pressure 8~9Kg/cm2. The maximum conversion rate was researched 74~76%.

This study aimed to evaluate the role of D-dimer in terminal cancer patients. Among 343 incurable cancer patients, only 4 patients (2.8%) had normal D-dimer levels, and the majority (n=115, 81.0%) had levels >2.0 μg/mL. The survival time was significantly differed according to D-dimer levels with a median of 48 days when D-dimer levels were <2 μg/mL and 19 days when D-dimer levels were higher. D-dimer levels were negatively correlated with survival according to Spearman’s rank correlation analysis (coefficient -0.335, p<0.001). In terminal cancer patients, D-dimer concentrations did exhibit prog-nostic significance.