PURPOSES: The purpose of this study is to develop an epidemic model considering interregional trips. METHODS : We developed the SIR-T model, which is an epidemic model of infectious diseases based on a metapopulation model considering the interactions between population groups. This model can consider the characteristics of the modes. A simulation was performed using this model to analyze the progress of the Middle East Respiratory Syndrome (MERS) in Korea, in 2015. RESULTS: The simulation results show that the spread of infectious diseases through passenger cars was the fastest and had the largest spread range. In the case of public transportation systems such as intercity buses, public railways, and high-speed railways, infectious diseases spread primarily at major terminal facilities and traffic facilities. CONCLUSIONS: The epidemic model of infectious diseases considering the interregional trips proposed in this study can be used as the base data for prevention strategy planning. However, a significant limitation is the lack of discussion on simulation parameter settings in this study, and further discussions are required in future studies.