To study the behavior of structures subject to blast loads it is important to calculate the loads due to the explosives accurately, especially in the case of interior explosions. It is known that numerical method based on computational fluid dynamics can estimate relatively accurate blast load due to the interior explosion including reflection effect. However, the numerical method has disadvantages that it is difficult to model the analysis and it takes much time to analyze it. Therefore, in this study, the analytical method which can include the reflection effect of the interior explosion was studied. The target structures were set as the slabs of residential buildings subject to interior explosion that could lead to massive casualties and progressive collapses. First, the numerical method is used to investigate the interior explosion effect and the maximum deflection of the slab which was assumed to be elastic, and compared with the analytical method proposed in this study. In the proposed analytical method, we determine the weighting factor of the reflection effect using the beam theory so that the explosion load calculation method becomes more accurate.