The antioxidant and anti-inflammatory effects of Corni fructus extracts (CEF, EtOAc extraction; CBF, buthanol extraction; CWF, water extraction) were investigated. The total phenolics of CEF (173.3 mg TAE/g) were significantly higher than those of CWF (26.7 mg TAE/g) and CBF (94.8 mg TAE/g). DPPH and ABTS free radical scavenging activity of CEF (DPPH: RH50; 25.1 μg/mL, ABTS: RC50; 36.1 μg/mL) showed even higher than that of BHA and α-tocopherol used as positive control. All three Corni fructus extracts in the concentration of 1~100 μg/mL were effective inhibitors of NO and prostaglandin E2 (PGE2). NO production was inhibited 71.3~92.2% by CEF, 76.8~85.5% by CBF and 74.4~96.9% by CWF, respectively. CEF, CBF and CWF (1~100 μg/mL) inhibited also pro-inflammatory cytokines like TNF-α, IL-1β and IL-6 very effectively. TNF-α was inhibited up to 51.2% by CWF and IL-1β was inhibited up to 67.1% by CEF. IL-6 was best inhibited by CEF up to 58.9%. This study suggested the potential of Corni fructus for use as an excellent antioxidant substance and inflammatory inhibiting mediators. Therefore CEF, CBF and CWF Corni fructus extracts may be used for therapeutic approach to various inflammatory diseases.