한국버섯학회지 제12권 제2호 (p.77-81)

A comprehensive review of the therapeutic effects of Hericium erinaceus in neurodegenerative disease

키워드 :
Hericium erinaceus,Nerve growth factor,Neurodegenerative disease,Blood-brain barrier

목차

ABSTRACT
INTRODUCTION
Areas of research
  Nerve Growth Stimulant
  In vitro model
In vivo model
Brain Function
Depression
Acknowledgements
Reference

초록

Mushrooms are considered not only as food but also for source of physiologically beneficial medicines.  The culinarymedicinal mushrooms may important role in the prevention of age-associated neurological dysfunctions, including  Alzheimer’s and Parkinson’s diseases. Hericium erinaceus (H. erinaceus), is edible mushrooms, is a parasitic fungus that  grows hanging off of logs and trees and well established candidate for brain and nerve health. H. erinaceus contains high amounts of  antioxidants, beta-glucan, polysaccharides and a potent catalyst for brain tissue regeneration and helps to improve memory and  cognitive functions. Its fruiting bodies and the fungal mycelia exhibit various pharmacological activities, including the enhancement of the  immune system, antitumor, hypoglycemic and anti-aging properties. H. erinaceus stimulates the synthesis of Nerve Growth  Factor (NGF) which is the primary protein nutrient responsible for enhancing and repairing neurological disorders. Especially  hericenones and erinacines isolated from its fruitin body stimulate NGF, synthesis. This fungus is also utilized to regulate blood levels  of glucose, triglycerides and cholesterol. H. erinaceus can be considered as useful therapeutic agents in the management and/or  treatment of neurodegeneration diseases. However, this review focuses on in vitro, in vivo and clinical trials for neurodegerative disease.