KOREASCHOLAR

Antioxidant activity of dropwort fermented extract (DFE) was measured according to fermentation period, and liverprotective effects were examined using Sprague-Dawley rats. Total polyphenol and flavonoid contents as well as DPPH andABTS radical scavenging activities increased up to 60~80 days and then decreased slightly. Proper fermentation time forDFE was more than 60 days and less than 80 days. Administration of alcohol to rats for 10 days at 10mL/kg/day raisedserum AST, ALT, total cholesterol, and triglyceride (TG) levels, which were then lowered by DFE and sugar liquid with thesame soluble solids. While sugar liquid increased the blood lipid profile, especially TG levels, DFE had no effect due to itsantioxidant activity. When TBARS content of the DFE group in liver tissue significantly decreased in a concentration-dependent manner compared to that of the ALH group (p<0.05). Liver damage was recovered by DFE treatment and wasconfirmed by hamatoxylin-eosin staining. These results suggest that DFE has a protective effect against alcohol-inducedhepatotoxicity in SD rats.

 I. 서 론  II. 연구 내용 및 방법   1. 실험재료   2. 밭미나리 발효액 제조   3. 밭미나리 발효액의 항산화 활성   4. 동물실험에서 밭미나리 발효액의 간 보호효과   5. 통계분석  III. 결과 및 고찰   1. 밭미나리 발효액의 항산화 활성   3. 동물실험에서 밭미나리 발효액의 간 보호효과  IV. 요약 및 결론  감사의 글  References

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• 김세미( 원광대학교 식품산업융복합학과) | 김세미
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• 이영은( 원광대학교 식품영양학과, 원광대학교 식품산업융복합학과) | 이영은