The purpose of this present study is to measure the changes of regional cerebral blood flow(rCBF) was continually monitored by laser-doppler flowmeter (Transonic Instrument, USA) through the data acquisition system composed of MacLab and Macintosh computer. Contractile force was measured with force displacement transducer under 1.5 g loading tension. Rhus verniciflua stokes increased the changes of rCBF in rats, significantly. The rCBF of Rhus verniciflua stokes was decreased by pretreated propranolol, l-NNA and methylene blue. But atropine indomethacin did not change the rCBF. Contractions evoked by PE 0.1μM were significantly inecreased by Rhus verniciflua stokes. Propranolol significantly altered the effect of Rhus verniciflua stokes, but l-NNA, ODQ and indomethacin did not change the relaxation of Rhus verniciflua stokes. These results suggest that Rhus verniciflua stokes can increase the rCBF and relax EP induced contraction of isolated rat aorta, and that is related to sympathetics and nitric
oxide.

• 김종천(원광대학교 한의과대학 약리학교실) | Jong-Chun Kim
• 이계복(원광대학교 한의과대학 약리학교실) | Gye-Bok Lee
• 최병화(원광대학교 한의과대학 약리학교실) | Byung-Hwa Choi
• 한상건(원광대학교 한의과대학 약리학교실) | Sang-Gun Han
• 한종현(원광대학교 한의과전문대학원) | Jong-Huyn Han