Anthocyanins, a class of flavonoids, are natural water-soluble pigments, which are mainly found in vegetables and fruits. Anthocyanins have attractive pharmacological activities, such as anti-oxidant, anti-inflammatory, anti-cancer, and anti-diabetic. The purpose of this study was to investigate the protective effects of anthocyanins-rich fraction (ANF) from Korean purple sweet potato variety, "Shinjami", against hydrogen peroxide (H2O2)-induced oxidative stress. In our results, pre-treatment of HepG2 cells with ANF (10μg/mL) significantly prevented cell death and maintained cell integrity, following exposure to 0.9 mM hydrogen peroxide. The H2O2-dependent production of intracellular ROS was also significantly decreased by pre-treatment with ANF (6 h, 10μg/mL). In addition, ANF increased the mRNA levels of antioxidant enzymes, catalase and glutathione level in H2O2-treated HepG2 cells. These results indicated that ANF protected HepG2 cells against H2O2-induced oxidative stress by inducing protective system.

• 장환희(농촌진흥청 국립농업과학원 기능성식품과) | Jang, Hwan Hee
• 남송이( 농촌진흥청 국립농업과학원 기능성식품과) | 남송이
• 김미주( 농촌진흥청 국립농업과학원 기능성식품과) | 김미주
• 김정봉( 농촌진흥청 국립농업과학원 기능성식품과) | 김정봉
• 김행란( 농촌진흥청 국립농업과학원 기능성식품과) | 김행란
• 이영민( 농촌진흥청 국립농업과학원 기능성식품과) | 이영민