Effects of dynamic high-pressure (DHP) treatments with and without integration with heating on microbial stability, vitamin C concentration, color, sugar content, and pH of orange juice were studied and compared with those of the conventional thermal treatment. Freshly squeezed orange juice was heated at 90oC for 1 min or DHP-treated at 205 MPa and 20, 50, 60, or 70oC. The DHP treatment at 20oC without heating and the treatment at 50oC inactivated indigenous mesophilic aerobic microorganisms in orange juice by 4.2 and >7 log CFU/mL, respectively. The DHPtreated juice exhibited brighter color and higher vitamin C concentration and sugar content than the thermally treated juice, regardless of integration with heating. The DHP-treated juice demonstrated brighter color and higher sugar contents than untreated juice and thermally treated juice during storage at 4oC for 63 days. The results have demonstrated the potential of applying DHP treatments to pasteurize orange juice with increasing brightness and sugar content of the juice.