For earthquake loss estimation of building structures in Gangnam-Gu district in Seoul, three scenario earthquakes were selected by comparison of the response spectra of these scenario earthquakes with the design spectrum in Korean Building Code (KBC 2009), and then direct losses of the building structures in the Gangnam-Gu district under each scenario earthquake are estimated. The following conclusions are drawn from the results of damage and loss in the second scenario earthquake, which has a magnitude = 6.5 and epicentral distance =15 km: (1) The ratio of building stocks undergoing the extensive and complete damage level is 40.0% of the total. (2) The amount of direct economic losses appears approximately 19 trillion won, which is 1.2% of the national GDP of Korea. (3) About 25% of high-rise (over 10-story) RC building wall structures, were inflicted with the damage exceeding moderate level, when compared to 60% of low-rise building structures. (4) From the economical view point, the main loss, approximately 50%, was caused by the damage in the high-rise RC wall building structures.