Garlic (Allium sativum) has been used as a medicinal plant due to its various functionalities such as reduction of cholesterol levels. The purpose of this study was to optimize conditions for the production of microencapsulated garlic powder (MGP) coated with whey protein isolate (WPI) to improve its production yield. WPI was mixed with distilled water followed by magnetic stirring at 500 rpm for 12 h to hydrate it completely. Garlic powder (GP) was added into the WPI mixture. Ratio of GP to WPI was 1:1. Subsequently, GP-WPI mixture was homogenized, and then spray-dried. To maximize the production yield of MGP, variables such as the mixing time and homogenizing condition such as rpm and time were tested. The optimum conditions for producing MGP were found to be as follows: GP and WPI mixing for 1 h and homogenizing at 8100 rpm for 10 min which improved liquid flow rate during spray drying process. The production yield of MGP under optimum conditions was 25.6 g/h. The results of this study might provide scale-up parameters on applications of GP for its commercialization.