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백서에서 창상 치유에 대한 Líght Emitting Diode(LED) 조사의 효과 KCI 등재

Effect of Light Emitting Diode(LED) Irradiation on Wound Healing of Ear Lobe in Rat

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대한구강악안면병리학회지 (The Korean Journal of Oral and Maxillofacial Pathology)
대한구강악안면병리학회 (Korean Academy Of Oral And Maxillofacial Pathology)
초록

LEDs have been shown to be a safe, efficient, light-weight, and less-expensive alternative to heal wound. LED irradiation at the same biostimulatory wavelength of previous laser studies have similar biochemical effects The purpose of present study is to evaluate the effects of wound healing by LED irradiation. Thirty 34-day-old sprague dawley were used for present study. 1.5mm diameter defected holes were formed in both ear lobes of rat by rubber dam punch. 635nm and 890nm irradiation was performed by LED for 2 weeks, followed by histologíc examination staíned with H&E and Masson trichrome. Also, RT-PCR was carried out to find out the mRNA expression level in gingival fjbroblast irradiated by 635nm for 1 hour. In gross exarnination, wound healing was observed in irradiated group comparing to control For microscopic exarnination, repair by connective tissues was filled in defects of irradiated group, while dense cellular bands consisting of fjbroblasts and capi llaries were found at the end of defect in control By staining of masson trichrome, amount of collagens were found in irradiated group. In a result of RT-PCR, mRNA expressions of TGF- ß , MMP-1,3 and Timp-3 were down-regulated in irradiated group comparing with their expression in control group. Taken together, LED irradiation increase the prolifeation and the activity of fibroblasts and down-regualted the TGF-ß , MMP- 1,3 and Timp- 3 mRNA, followed by activation of would healing.

저자
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  • 고미경(전남대학교 치과대학 구강병리학교실 및 치의학연구소) | Mi Kyeong Ko
  • 장미선(전남대학교 치과대학 구강병리학교실 및 치의학연구소) | Mi Sun Jang
  • 국은별(전남대학교 치과대학 구강병리학교실 및 치의학연구소) | Eun Byu KooK
  • 정권(전남대학교 치과대학 구강병리학교실 및 치의학연구소) | Kwon Jung
  • 장윤영(전남대학교 치과대학 구강병리학교실 및 치의학연구소) | Youn Young Jang
  • 정민아(전남대학교 치과대학 구강병리학교실 및 치의학연구소) | Min A Chung
  • 양재혁(전남대학교 치과대학 구강병리학교실 및 치의학연구소) | Jae Hyuck Yang
  • 임채광(전남대학교 치과대학 구강병리학교실 및 치의학연구소) | Chae Kwang Lim
  • 임원봉(전남대학교 산학협력공학관 바이오포톤) | Won Bong Lim
  • 박진수(전남대학교 산학협력공학관 바이오포톤) | Jin Soo Park
  • 김옥준(전남대학교 치과대학 구강병리학교실 및 치의학연구소) | Ok Joon Kim
  • 최홍란(전남대학교 치과대학 구강병리학교실 및 치의학연구소) | Hong Ran Choi