A combined treatment system using multiple source water is becoming important as an alternative to conventional water supply for small-scale water systems. In this research, combined water treatment systems were investigated for simultaneous use of multi-source water including rainwater, ground water, river water, and reclaimed wastewater. A laboratory-scale system was developed to systematically compare various combinations of water treatment processes, including sand filtration, microfiltration (MF), granular activated carbon (GAC), and nanofiltration (NF). Results showed that the efficiency of combined water treatment systems was affected by the quality of feed waters. In addition, a simply approach based on the concept of linear combination was suggested to support a decision-making for the optimum water treatment systems with the consideration of final water quality.