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돼지 난자의 체외성숙과 배아발달 동안 ROS와 항산화제의 영향

Effects of Reactive Oxygen Species and Antioxidants during In vitro Maturation Oocytes and Embryo Development in Pigs

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  • URLhttps://db.koreascholar.com/Article/Detail/327994
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한국동물번식학회 (The Korean Society of Animal Reproduction)
초록

The oocyte undergoes various events during In vitro maturation (IVM) and subsequence development. One of the events is production of reactive oxygen species (ROS) that is a normal process of cell metabolism. But imbalances between ROS production and antioxidant systems induce oxidative stress that negatively affect to mammalian reproductive process. In vitro environments, In vitro matured oocytes have many problems, such as excessive production of ROS and imperfect cytoplasmic maturation. Therefore, In vitro matured oocytes still have lower maturation rates and developmental competence than in vivo matured oocytes. In order to improve the IVM and In vitro culture (IVC) system, antioxidants, vitamins were added to the IVM, IVC medium. Antioxidant supplementation was effective in controlling the production of ROS and it continues to be explored as a potential strategy to overcome mammalian reproductive disorders. Based on these studies, we expect that the use of antioxidants in porcine oocytes could improved maturation and development rates.

저자
  • 이원희(강원대학교 동물생명과학대학) | Won-Hee Lee (College of Animal Life Sciences, Kangwon National University, Chuncheon 24341, Republic of Korea)
  • 박지은(강원대학교 동물생명과학대학) | Ji-Eun Park (College of Animal Life Sciences, Kangwon National University, Chuncheon 24341, Republic of Korea)
  • 황보용(강원대학교 동물생명과학대학) | Yong Hwangbo (College of Animal Life Sciences, Kangwon National University, Chuncheon 24341, Republic of Korea)
  • 김화영(강원대학교 동물생명과학대학) | Hwa-Young Kim (College of Animal Life Sciences, Kangwon National University, Chuncheon 24341, Republic of Korea)
  • 이지은(강원대학교 동물생명과학대학) | Ji-Eun Lee (College of Animal Life Sciences, Kangwon National University, Chuncheon 24341, Republic of Korea)
  • 강병범(강원대학교 동물생명과학대학) | Byeong-Buhm Kang (College of Animal Life Sciences, Kangwon National University, Chuncheon 24341, Republic of Korea)
  • 정희태(강원대학교 수의과대학) | Hee-Tae Cheong (College of Veterinary Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea)
  • 양부근(강원대학교 동물생명과학대학) | Boo-Keun Yang (College of Animal Life Sciences, Kangwon National University, Chuncheon 24341, Republic of Korea)
  • 박춘근(강원대학교 동물생명과학대학) | Choon-Keun Park (College of Animal Life Sciences, Kangwon National University, Chuncheon 24341, Republic of Korea) Corresponding author