The aim of this research is to evaluate the impact of various process conditions on the physical properties and digestibility of extruded fish feed at different barrel temperatures (120, 130, and 140oC) and moisture contents (35, 40, and 45%). The expansion ratio decreased with increasing the moisture content. The hardness was negatively correlated with the expansion ratio. The bulk density decreased by increasing moisture content. The water holding capacity increased by increasing the moisture content and barrel temperature. Soaking time significantly (p<0.05) affected water stability and the best water stability was observed in all samples soaked for 1 h, but water stability was also stable at 2 h and 3 h. There was a significant increase in the protein digestibility of extruded fish feed, compared to that of the raw material.