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홍삼가수분해농축액 (GS-E3D)의 급성 경구 및 경피 독성 시험 평가

Evaluation of Acute oral and Dermal Toxicity of Pectinase Lyase-modified Red Ginseng (GS-E3D)

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  • URLhttps://db.koreascholar.com/Article/Detail/362872
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한국약용작물학회 (The Korean Society of Medicinal Crop Science)
초록

Background : Pectin lyase-modified red ginseng extract (GS-E3D) is a newly developed ginsenoside Rd-enriched ginseng extract. This study was designed to investigate the acute oral and dermal toxicity of GS-E3D in rat.
Methods and Results : The acute oral toxic effects of GS-E3D in female SD rats were examined at dosages of 300 ㎎/㎏ and 2,000 ㎎/㎏. In acute dermal toxicity study, 500, 1,000 and 2,000 ㎎/㎏ of GS-E3D were applied onto the shaved skin of male and female SD rats. The weights of rats were recorded at 0, 1, 3, 7, and 14 days and clinical observation were checked once a day for a period of 14 days. All rats were scarified on 14th day and complete gross examination was conducted to detect any gross change of organs after necropsy. GS-E3D did not produce orally or dermally treatment-related clinical signs of toxicity or mortality in all rats during the 14-day observation period. The oral and dermal LD50 values of GS-E3D were over 2,000 ㎎/㎏ in rat. The oral and dermal administration of GS-E3D revealed no significant change in body weight and gross pathology examination compared to control group.
Conclusion : These results indicate that GS-E3D can be used as a food and cosmetic materials without critically adverse effect.

저자
  • 표미경((재)금산국제인삼약초연구소) | Mi Kyung Pyo Corresponding author
  • 이경희((재)금산국제인삼약초연구소) | Gyeong Hee Lee
  • 김진성((재)금산국제인삼약초연구소) | Jin Seong Kim
  • 조윤호((재)금산국제인삼약초연구소) | Yun Ho J
  • 이유진((재)금산국제인삼약초연구소) | You Jin Lee
  • 정다유((재)금산국제인삼약초연구소) | Dayu Jung
  • 유대석((재)금산국제인삼약초연구소) | Dae Seok Yoo
  • 김원용((재)금산국제인삼약초연구소) | Won Yong Kim
  • 차선우((재)금산국제인삼약초연구소) | Seon Woo Cha
  • 박기용((주)세화피앤씨) | Ki Young Park
  • 이기무((주)세화피앤씨) | Ki Moo Lee