Purpose: The purpose of this study was to investigate the effectiveness of pre-briefing in simulation-based learning on nursing students’ satisfaction with simulation. Method: A quasi-experimental post-test study was applied with 174 senior nursing students at a private university in South Korea. The experimental group (n=88) underwent a pre-briefing program, whereas the control group (n=86) did not. During pre-briefing, students had time to study simulation scenarios, discuss nursing processes related to simulation scenarios, and experience a simulation environment before simulation practice. Satisfaction scores were measured using the Satisfaction with Simulation Experience scale(SSE). Results: The mean scores in satisfaction with simulation were higher in the experimental group than in the control group, and the difference was statistically significant (t=-4.23, p<.001). Conclusion: This study emphasizes that pre-briefing in simulation-based learning is important in increasing students’ satisfaction and should be included in the planning of simulation-based learning programs.