Purpose: The purpose of this study was understanding of real experiences of the subjects taking anti-psychotics medication. Methods: The subjects of this study were 14 mentally ill patients hospitalized in C National Hospital. The interview data were analyzed with ethnography researchmethod. Results: 26 themes were drawn, and they were categorized into 5 categories. The 1st category was the stage not to acknowledge themselves as mentally ill patients, as mentally ill patients were forced to be hospitalized in the mental hospital by their family, when their mental illness developed. The second category was the stage to endure difficulties while taking medication. The third category was the stage to experience recurrence of disease. The fourth category is the stage to experience improvement of mental illness with medication. The fifth category is the stage to reflect thembecause of the improvement of mental illness, and to express confidence and will about medication after being discharged from the hospital. Conclusion:Nurses actually have to provide total care bymaking thementally ill patients feel comfortable not to have resistance about medication, when they are hospitalized, closely observing medication actions and side effects, and sharing difficulties felt by the patients.