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한국식품저장유통학회지 (Korean J. Food Preserv.)
(한국식품저장유통학회지)
제16권 제3호 (2009.06)
pp.449-453
pp.449-453
한국식품저장유통학회
(The Korean Society of Food Preservation)
초록
The experiment was conducted to validate anti-inflammatory effects of pinitol from bean. It was evaluated for some molecule targets by wound healing assay and RT-PCR. The results of wound healing assay was shown dose-dependent inhibition of cell migration in cancer cells and inhibited RNA expression of ICAM-1, CD 44, MMP-17, MMP-14 and ARF2. Immune suppression activity in a mouse provoked by DNFB observed that inflammatory reaction with pinitol were reduced ear swelling and inflammatory cells infiltration in mouse atopic models. The result confirmed that pinitol have the effect of dose-dependent immune suppression activity.
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