To evaluate the anti-tumor activity of Flammulina velutipes extract, we used an in vitro wound-healing assay, and an in vivo approach using a mouse melanoma model. Wound-healing activity in B16 cells was affected by the extract in a dose-dependent manner, indicating that the extract had anti-metastatic activity. The extract also exhibited strong anti-tumor activity against lung cancer when B16 cells were injected into mouse veins together with B16 melanoma cells. The results indicatethat the Flammulina velutipes extract decreased B16 cancer cell growth by inhibition of cell migration both in vitro and in vivo.

• 이시림(경북대학교 농업생명과학대학 식품공학과)
• 남동윤(경북대학교 농업생명과학대학 식품공학과)
• 이현진(경북대학교 농업생명과학대학 식품공학과)
• 박철홍(경북대학교 농업생명과학대학 식품공학과)
• 허진철(경북대학교 농업생명과학대학 식품공학과)
• 김종국(경북대학교 농업생명과학대학 미생물학과)
• 이진만(호서대학교 식품생물공학과)
• 이창윤(그린합명회사)
• 박희주(그린합명회사)
• 이상한(경북대학교 농업생명과학대학 식품공학과) Corresponding author