논문 상세보기
pp.109-114
Nepal産인 Nepal pseudo ginseng(NPG)의 大根과 小根 2종에 있어서 물추출 성분과 ethanol 침전성분이 암독소(Toxohormone-L)가 유도하는 지방분해에 미치는 영향을 관찰하고자 본 연구를 시도하였다. 지방질 분해인자로 알려진 독소호르몬-L은 Sarcoma180痛생쥐의 복수증액으로부터 부분정제하여 이용하였다. 암독소가 유도하는 지방분해 저해능은 반응의 최종농도가 500 및 1, 000 dalton 일 때 大根의 NPG은 ethanol 침전성분(평균 55.5%)이 물추출 성분보다 평균 1.37배 더 높았으나 小根의 NPG는 반대로 물추출 성분(평균 55.5%)이 평균 1.14배 더 높았다. 한편 대근의 NPG의 ethanol 침전성분이 지방분해에 미치는 저해능(47.6%)을 최종 반응농도가 1, 000㎍/㎖일 때 고려홍삼의 ethanol 침전성분(79.8%)에 비교하면 약 60%에 불과하였다.
This study was divised to observe an inhibitory effect toward a lipolytic action of toxohormone-L from large root and small root Nepal pseudo ginseng(NPG: Nepal products) components by water extract and ethanol precipitate in vitro. Toxohormone-L is known to be a lipolytic factor that was partially purified from the ascites fluid of Sarcoma 180-bearing mice and of patients with hepatoma. The inhibitory effect that inhibited the lipolytic action of toxohormone-L by ethanol precipitate component of large root NPG (mean 55.5%) was higher (mean 1.37 times) than that of water extract component in final reaction concentration of 500 and l, 000㎍/㎖, on the other side inhibitory effect of water extract component in small root NPG(mean 55.5%) was higer(mean 1.14 times) than that of ethanol precipitate component. In a way inhibitory effect of precipitate component in large root NPG (47.6%), when final reaction concentration of sample were l, 000㎍/㎖, was about 40% lower than that of Korean red ginseng.
