Purpose: This study aimed to examine the effects of cardiopulmonary resuscitation education via the jigsaw cooperative learning on the knowledge, attitude, self-efficacy, self-efficacy for group work, and self-regulation of baccalaureate nursing students. Methods: This one-group pretest-posttest experimental design study was conducted from April 20 to June 10, 2022. It included 27 baccalaureate nursing students. The collected data were analyzed by descriptive statistics and the Wilcoxon signed-rank test using Statistical Product and Service Solutions for Windows, version 25.0. Results: The results showed statistically significant improvements after the educational intervention program. The level of cardiopulmonary resuscitation knowledge (Z=-4.22, p<.001), cardiopulmonary resuscitation self-efficacy (Z=-3.84, p<.001), self-efficacy for group work (Z=-2.83, p=.005), and self-regulation (Z=-2.70, p=.007) improved significantly. Conclusion: These findings suggest the necessity of continuous cardiopulmonary resuscitation education and cooperative learning. Thus, it is necessary to conduct repeated studies on cardiopulmonary resuscitation education by applying various teaching methods for nursing students.