The high-level radioactive waste repository must ensure its performance for a long period of time enough to sufficiently reduce the potential risk of the waste, and for this purpose, multibarrier systems consisting of engineered and natural barrier systems are applied. If waste nuclides leak, the dominating mechanisms facilitating their movement toward human habitats include advection, dispersion and diffusion along groundwater flows. Therefore, it is of great importance to accurately assess the hydrogeological and geochemical characteristics of the host rock because it acts as a flow medium. Normally, borehole investigations were used to evaluate the characteristics and the use of multi-packer system is more efficient and economical compared to standpipes, as it divides a single borehole into multiple sections by installing multiple packers. For effective analyses and groundwater sampling, the entire system is designed by preselecting sections where groundwater flow is clearly remarkable. The selection is based on the analyses of various borehole and rock core logging data. Generally, sections with a high frequency of joints and evident water flow are chosen. Analyzing the logging data, which can be considered continuous, gives several local points where the results exhibit significant local changes. These clear deviations can be considered outliers within the data set, and machine learning algorithms have been frequently applied to classify them. The algorithms applied in this study include DBSCAN (density based spatial clustering of application with noise), OCSVM (one class support vector method), KNN (K nearest neighbor), and isolation forest, of which are widely used in many applications. This paper aims to evaluate the applicability of the aforementioned four algorithms to the design of multi-packer system. The data used for this evaluation were obtained from DB-2 borehole logging data, which is a deep borehole locates near KURT.