This study investigated the effect of Lactiplantibacillus plantarum JSA22-fermented rice drinks on dextran sodium sulfate (DSS)-induced colitis in mice. Twenty-four mice were randomly assigned; No colitis (Con), colitis with tap water (DSS-only), colitis with unfermented rice (DSS-UFR), and colitis with fermented rice (DSS-FR). After inducing colitis with 2% DSS for 5 days, they were given Tap water, UFR drink, or FR drink for an additional 6 days. The DSS-FR group had significantly lower Disease Activity Index (DAI) scores compared to the DSS-only group, but no significant difference with the DSS-UFR group. Colon length was reduced in the DSS-only group. The DSS-only group had significantly higher IL-6 mRNA levels compared to the Con group, while the DSS-FR groups showed significantly lower IL-6 mRNA levels compared to the DSS-only group. These results suggest that rice drinks fermented with Lactiplantibacillus Plantarum JSA22 ameliorate the severity of DSS-colitis, by potentially reducing proinflammatory cytokines.

서 론
재료 및 방법
    1. Lb. plantarum JSA22를 이용한 쌀 발효물 제조
    2. 실험 동물
    3. 대장염 유도 및 시료 투여
    4. 질병활성도 측정
    5. 루미놀 반응 검사
    6. 대장 길이 측정 및 조직 채취
    7. RNA 분리, cDNA 합성 및 RT-qPCR 분석
    8. 통계학적 분석
결과 및 고찰
    1. 대장염 증상 개선 효과
    2. 대장 길이 변화에 대한 효과
    3. 전염증성 사이토카인에 대한 효과
요약 및 결론
감사의 글
References

• 유지송(원광대학교 의과대학 생리학교실 석사과정생) | Jisong You (Master’s Student, Dept. of Physiology, Digestive Disease Research Institute, Wonkwang University School of Medicine, Iksan 54538, Korea)
• 선다현(원광대학교 의과대학 생리학교실 석사과정생) | Dahyun Seon (Master’s Student, Dept. of Physiology, Digestive Disease Research Institute, Wonkwang University School of Medicine, Iksan 54538, Korea)
• 최현석(원광대학교 의과대학 생리학교실 박사과정생) | Hyun Seok Choi (Doctor’s Student, Dept. of Physiology, Digestive Disease Research Institute, Wonkwang University School of Medicine, Iksan 54538, Korea)
• 김민섭(원광대학교 의과대학 생리학교실 연구교수) | Min Seob Kim (Research Professor, Dept. of Physiology, Digestive Disease Research Institute, Wonkwang University School of Medicine, Iksan 54538, Korea)
• 유명환(원광대학교 의과대학 생리학교실 박사과정생) | Myeong Hwan Yu (Doctor’s Student, Dept. of Physiology, Digestive Disease Research Institute, Wonkwang University School of Medicine, Iksan 54538, Korea)
• 진종식(전북대학교 한약자원학과 교수) | Jong Sik Jin (Professor, Dept. of Oriental Medicine Resources, Jeonbuk National University, Iksan 54596, Korea)
• 김동근(전북대학교 한약자원학과 석사과정생) | Dong Keun Kim (Master’s Student, Dept. of Oriental Medicine Resources, Jeonbuk National University, Iksan 54596, Korea)
• 최혜선(농촌진흥청 농업연구사) | Hye Sun Choi (Researcher, National Institute of Crop Science, Rural Development Administration, Suwon 16613, Korea)
• 박정호(강북삼성병원 소화기내과 교수) | Jung Ho Park (Professor, Dept. of Gastroenterology, Kangbuk Samsung Hospital, Seoul 03181, Korea)
• 김용성(주식회사 것앤드푸드헬스케어 수석연구원) | Yong Sung Kim (Chief Researcher, Gut & Food Healthcare Co., Ltd., Seongnam 13528, Korea)
• 이문영(원광대학교 의과대학 생리학교실 교수) | Moon Young Lee (Professor, Dept. of Physiology, Digestive Disease Research Institute, Wonkwang University School of Medicine, Iksan 54538, Korea) Corresponding author