This study aimed to develop a comprehensive validation methodology for an Infra-guidance system, which is an infrastructure-based service aimed at enhancing the safety of autonomous driving. The proposed method includes quantitative techniques for validating both the Infra-guidance algorithm module and the guidance message module using each optimal indicator. In addition, a promising method is suggested to validate the entire system by applying a multicriteria decision methodology. The relative weight for the algorithm module was higher than relative weight for the message module. Moreover, the relative weight of the latency for the message module was slightly higher than weight of the packet error rate. The proposed methodology is applicable for validating the performance of infrastructure-based services for enhancing connected autonomous driving based on the comprehensive quantification of various factors and indicators.