Purpose: This study aimed to identify the status of medication errors by nurses using patient safety incident reports and to gain a detailed understanding of nurses' experiences with medication errors. Methods: An explanatory sequential mixed-methods design was used, combining a retrospective analysis of 204 patient safety incident reports on nurses’ medication errors with a qualitative study that explored the experiences of eight nurses through thematic analysis. Results: Most of the medication errors occurred during day shifts in intensive and trauma intensive care units. Injectable drugs accounted for 37.7% of errors, with dosage errors being most frequent. Although 67.6% of incidents resulted in no adverse effects, 65.7% were classified as adverse events, and 89.2% of predicted outcomes indicated potential physical harm to patients. Qualitative analysis of interviews yielded 36 meaningful statements, organized into 11 sub-themes and 3 main themes: (1) the whirlwind of negative emotions caused by medication errors, (2) obstacles in the clinical environment hindering adherence to medication principles, and (3) insights and reflections gained from medication error experiences. Conclusion: Organizations can prevent medication errors by improving workload distribution, ensuring safe environments, addressing staffing shortages, promoting a patient safety culture, and providing psychological support for affected nurses to improve their mental health and productivity.