Cudraxanthone D (CD) is a natural xanthone compound derived from the root barks of Cudrania tricuspidata . However, the biological functions of CD in human metabolism have been rarely reported until now. Autophagy is the self-degradation process related to cancer cell metastasis. Here, we elucidated the effects of CD on human oral squamous cell carcinoma (OSCC) cells’ metastatic ability. We confirmed that CD effectively decreased the proliferation and viability of SCC25 human OSCC cells in time- and dose-dependent manners. Also, the metastasis phenotype of the SCC25 cell (migration, invasion, and epithelial–mesenchymal transition [EMT]) was inhibited by CD. To further investigate the mechanism by which CD inhibited the metastatic capacity, we detected the relationship between EMT and autophagy in the SCC25 cells. The results revealed that CD inhibited the metastasis of the SCC25 cells by attenuating autophagy. Thus, our findings produced a potential novel agent for the treatment of human OSCC metastasis.

The primary purpose of this research is to propose the solution to the current crisis of the WTO dispute settlement system focusing on Article 25 of the WTO Agreement. The Dispute Settlement Understanding is one of the significant successes of the WTO. Recent years, however, have witnessed the difficulties and challenges facing the multilateral trading system along with rising anti-globalization and trade protectionism. The Appellate Body (AB) has been experiencing an unprecedented crisis of dysfunction mainly due to the US’s boycott of appointing the new members. The WTO Members, including China, have thus proposed various reforms in response to the crisis. However, they have not touched the core demands of the US. Because of the imminent crisis that the AB is about to stop operating, China should take urgent action with other WTO members, consider launching a majority voting program, design and use alternative appeal arbitration, and combine international rules with domestic deepening reforms.

To meet the increased performance and cost requirements of commercial supercapacitor, a N and O self-doped hierarchical porous carbon is fabricated via a green and simple self-activation route utilizing leaves of wild hollyhock as raw materials. Comparing to commercial activated carbon, the reported material exhibits some marked merits, such as simple and green fabrication process, low cost, and superior capacitance performance. The specific surface area of the obtained N and O codoped hierarchical porous carbon arrives 954 m2 g−1, and the content of the self-doped nitrogen and oxygen reaches 2.64 at.% and 7.38 at.%, respectively. The specific capacitance of the obtained material reaches 226 F g− 1 while the specific capacitance of the symmetric supercapacitor arrives 47.3 F g− 1. Meanwhile, more than 90.3% of initial specific capacitance is kept under a current density of 20 A g− 1, and no arresting degradation is observed for capacitance after 5000 times cycle, perfectly demonstrating the excellent cycle and rate capability of the obtained material. The obtained N and O co-doped hierarchical porous carbon are expected to be an ideal substitution for commercial activated carbon.

Foaling is a process of giving birth to foal which is prompt and forceful event in equine breeding. Dystocia is declared when 2nd stage of parturition exceeds from 20 min without fetal movements in mare. Dystocia is very challenging situation for both mare and veterinarian. Survivability of mare and foal, and subsequent fertility of mare depends on efficient management. Therefore, the current report described a rare case of wry neck (torticollis or unilateral bent neck) resulted in dystocia, that was efficiently resolved by partial fetotomy and repulsion technique in mare under field conditions. Intensive post operative care was performed to avoid infection and to achieve fertility subsequently.

맵시벌상과에 속하는 Testudobracon pleuralis Ashmead, 1906, Diadromus subtilicornis Gravenhorst 1829 2속 및 2종을 한국에서 처음으로 보고한다. 본 종의 형태진단, 분포, 삽화를 수록한다.

We report the discovery of a giant exoplanet in the microlensing event OGLE-2017-BLG-1049, with a planet―host star mass ratio of q = 9.53 ± 0.39 × 10-3 and a caustic crossing feature in Korea Microlensing Telescope Network (KMTNet) observations. The caustic crossing feature yields an angular Einstein radius of θE = 0.52 ± 0.11 mas. However, the microlens parallax is not measured because the time scale of the event, tE ≃ 29 days, is too short. Thus, we perform a Bayesian analysis to estimate physical quantities of the lens system. We find that the lens system has a star with mass Mh = 0.55+0.36 -0.29 M⊙ hosting a giant planet with Mp = 5.53+3.62 -2.87 MJup, at a distance of DL = 5.67+1.11 -1.52 kpc. The projected star{planet separation is aㅗ = 3.92+1.10 -1.32 au. This means that the planet is located beyond the snow line of the host. The relative lens{source proper motion is μrel ~ 7 mas yr-1, thus the lens and source will be separated from each other within 10 years. After this, it will be possible to measure the flux of the host star with 30 meter class telescopes and to determine its mass.

A combination of Polycarbonate (PC) material and Polymethylmethacrylate (PMMA), fabricated using an injection molding machine, has been investigated to determine its advantages, as studied in Ref. 1). This paper aims to investigate the optimization of PMMA/PC blend for both tensile yield strength and impact strength. Furthermore, interaction effects of process conditions on mechanical properties including tensile yield strength and impact strength of PMMA/PC blend by injection molding process are interpreted in this study. Tensile and impact specimens are designed following ASTM, type V, and are fabricated by injection molding process. The processing conditions such as melt temperature, mold temperature, packing pressure, and cooling time are applied; each factor has three levels. As a result, in comparison with optimization of separated responses, mechanical properties of PMMA/PC are found to decrease when optimizing both tensile and impact strengths simultaneously. The melt temperature is found to be the most significant interaction parameter with the mold temperature and packing pressure. In addition, there is more interaction between the mold temperature and cooling time. This investigation provides a useful understanding of the control of injection molding processing of polymer blends in optical application.

목적 : 본 연구에서는 노안을 대상으로 멀티포컬 콘택트렌즈 착용 후 조도에 따른 시력의 변화를 확인하고 시 력의 개선 방안을 모색하고자 하였다. 방법 : 평균연령 55.39±4.25세의 중년 중 교정 시력 0.8 이상, 난시 0.75 미만의 노안 26명을 대상으로 하였 다. 중심-근용 Dailies Total1® Multifocal contact lenses(Alcon)을 2주간 착용 후 검사를 진행하였다. 검사실 조도를 1,000, 100, 10 lx로 설정하였고, 멀티포컬 콘택트렌즈 착용 시 원거리 동공크기는 3 m, 근거리 동공크기는 40 cm에서 동공자를 사용해 측정하였다. 원거리 시력은 ETDRS(Early Treatment Diabetic Retinopathy Study, Precision-Vision, USA)시표, 근거리 시력은 Adult Near Contrast Test #587700 (GOOD-LITE, USA)의 ETDRS 시표를 이용하여 고대비시력 및 저대비시력을 측정하였다. 결과 : 멀티포컬 콘택트렌즈 착용 시 조도가 증가함에 따라 동공 크기는 감소하였다(p<0.050). 멀티포컬 콘택트 렌즈 착용 시 고대비시력 및 저대비시력은 원·근거리에서 조도가 증가함에 따라 유의하게 증가하였다(p<0.050). 멀티포컬 콘택트렌즈 착용 시 시력은 안경 착용과 비교하여 원거리 시력은 대부분 유의한 차이가 없으나(p>0.050), 100, 10 lx의 원거리 고대비시력과 모든 조도의 근거리 시력은 유의하게 감소하였다(p<0.050). 낮은 실내조도인 10 lx에서 추가적인 조명을 사용한 경우에는 근거리 고대비시력과 저대비시력 모두 유의하게 개선되었다(p<0.050). 결론 : 멀티포컬 콘택트렌즈 착용 시 시력은 조도에 큰 영향을 받으며, 밝은 외부 조도에서의 시력은 안경과 차 이가 없었고, 낮은 조도에서는 추가적인 조명을 사용할 경우 시력이 개선되었다.

이 연구는 스마트 온실의 온습도 데이터를 수집하고, 그 환 경 요인들 간의 상관관계를 분석하여 스마트 온실 환경관리의 기초자료를 제공하고자 수행되었다. 스마트팜 시스템이 도입된 토경 방식의 OS 온실과 암면 배지경 방식의 KB 온실을 대 상으로 기온, 근권온도, 상대습도의 항목에서 매일 24시간의 데이터를 수집하였고, 이중 최고와 최저, 일평균, 주간 평균, 야간 평균, 일교차의 여섯 가지로 세분하여 정리한 후 두 온실 간의 차이와 기온과 근권온도의 상관관계를 분석하였다. 장미의 생육적온은 주간, 야간, 일교차는 이며, 근권온도는, 습도 는 95% 미만을 유지하는 것이 좋다. 두 온실의 실제 환경과 장미의 적정 환경 조건을 비교했을 때, 주간 기온은 OS 온실 에서 5개월 간, KB 온실에서 7개월 간 적정 수준(24~27˚C)을 유지하였다. 야간 기온은 두 온실 모두 2개월간 적정 수준 (15~18˚C)을 유지하였고, 일교차는 OS 온실에서 6개월간, B 온실은 9개월 간 적정 수준(약 10˚C)에 근접하였다. 근권온도 는 OS 온실에서 10개월, KB 온실에서 5개월간 적정 수준 (20~25˚C)을 유지한 반면, 상대습도는 두 온실 모두 연중 적정 범위 내에 들었다. 기온과 근권온도의 상관관계를 분석한 결 과, OS 온실은 최고 온도, 평균 온도, 주간 온도, 야간온도에 서는 뚜렷한 상관관계를, 최저온도와 일교차에서는 약한 상관 관계를 보였으며, KB 온실에서는 전 영역에서 매우 강한 직선 적 비례 관계를 보였다. 결론적으로 토경재배를 실시하는 OS 온실이 고설식 암면배지경을 실시하는 KB 온실에 비해 근권 온도가 기온의 영향을 덜 받았으며, 완충능력이 높은 토경재 배에서는 기온의 영향을 덜 받는다고 볼 수 있다.

Seaports are under high-speed developing and booming with the extend of the facilities and equipment to support the port activities and industry’s needs. It may bring environment destruction due to the change of the environmental conditions, likes forests, soils, water, and air. Therefore, this paper aimed to analyze the negative environmental impact due to seaport activities in Malaysia. The priority dominant factors are determined through analytic hierarchy process (AHP). Malaysia Port is selected as case study and 20 respondents are selected from virous department based on their expertise. Pari-wise comparison survey is used to collect data. The results shown that the negative environmental impact’s main elements are water (0.451), noise (0.262), organism (0.181), and air (0.106). Meanwhile, the toxicity is the prominent negative environmental impact’s sub-element of port activities, which scored 0.241, followed by interfering communication (0.142), and smell (0.134). The CR values are less than 0.1 and are considered acceptable. Hence, the outcome of the paper stimulated public awareness toward environmental protection. The development and expansion of seaports must consider environment conservation and preservation, and it cannot bring irreparable sequelae to the earth.

Bulk carrier ship type is one of the three dominant types of merchant vessels along with container ships and tankers. Recently, in terms of tonnage, bulk carriers constitute about the world's fleet third. The stuff materials indigence such as grains, fertilizers, ores, etc. Since the turn of the millennium, the number has increased considerably. Recently, a growing variance in bulk cargo which has transported by sea, represents now a large part of international commercial exchange shipped by sea. Every year there are huge number tons of cargoes like steel, coals, livestock feed, copper and minerals that are transported by sea in bulk. While most of those shipments are made without accidents, a number of serious injuries have occurred which have resulted not only in the ship's loss, but also in lives loss. In this paper, there is an existing bulk carrier vessel, a computational case study, is made to investigate the different loading conditions effects and bulk cargoes’ types on ship’s stability, in case of damaged conditions, in addition to the effect on the ship’s hull longitudinal strength. A proposed method is suggested to improve the level of safety of the ship past flooding by the usage of air bag (cushion). The candidate vessel consists of two cargo holds. In this paper there are three investigated damage scenarios, the first one is checking the stability in case of damage of cargo hold No.1. The second one is checking the stability in case of damage of cargo hold No.2 and the third scenario is checking the stability in case of flooding of both of the two cargo holds. There’s a modelling software, Auto Ship, is used here to model the vessel, simulate the different scenarios and to run the stability code to check the stability criteria. Finally, after performing the above mentioned three damage scenarios, the result was that the ship will still float in case of scenario one or two but in case of the third scenario, it will sink. So, this study has suggested a way to keep the vessel floating in case of the third scenario until reaching the nearest port without sinking. This proposed method is by using air cushions to open directly in case of existing alarm in the bulk carrier work to fill all the space inside the cargo hold instead of filling with the water.

In the maritime industry, most perceptions, frameworks and methodologies of dealing with hazards are for their risk assessment rather than their risk management. This tendency discloses the reality that within the maritime sectors in areas like shipping, logistics, oil and gas there is a lack of coherent Quantitative Risk Management (QRM) methodology from which to understand the risk-based decisions especially for appropriate risk management such as in seaports’ terminals. Therefore, in this paper initially, during priority assessment of the identified hazards, Fuzzy Set Theory was applied to handle imprecision of the uncertain risk-based statistics to get an accurate result. In the next stage, Fuzzy Fault Tree and Fuzzy Event Tree methods were used to achieve the sequence of quantitative risk analysis. In the final step, a Fuzzy Technique for Order of Preference by Similarity to Ideal Solution tool was used for the implementation of the mitigation phase to complete and conclude the proposed QRM cycle.

Systematic literature reviews (SLR) are very important to track the extent to which studies related to the formulation of Halal Catering on board have been previously studied by previous scholars. Therefore, the SLR study requires a clear and detailed understanding concerning the study direction for each selected article by analyzing the scope of the study and its dimensions as the main emphasis whether it has been discussed by any previous scholar or otherwise. Through the basis of the analysis of literature reviews will enable the specific detection of the title of the study. Even SLR analysis is also able to compare in terms of the year the article was published by comparing the differences in scope and dimensions of each article by selected scholars referred to 16 scholars from the year 2012 until 2017. Regards to methodology, SLR emphasised into five stages such as i) Time Frame, ii) Selection of a database, iii) Journal selection, iv) Article selection and v) Literature review analysis. Analysis, discussion, and findings will be focusing on the scope, dimensions, and years of studies by using figures, tables as facilitators of analysis and findings. Hence, the role of Halal institutions will be able to assess its ability to form halal rules with the involvement of stakeholders and the scope that has been affected in detail.

In this work, Ag3PO4/In2S3 nanocomposites with low loading of In2S3 (5-15 wt %) are fabricated by two step chemical precipitation approach. The microstructure, composition and improved photoelectrochemical properties of the asprepared composites are studied by X-ray diffraction pattern (XRD), field emission scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), photocurrent density, EIS and amperometric i-t curve analysis. It is found that most of In2S3 nanoparticles are deposited on the surfaces of Ag3PO4. The as-prepared Ag3PO4/ In2S3 composite (10 wt%) is selected and investigated by SEM and TEM, which exhibits special morphology consisting of lager size substrate (Ag3PO4), particles and some nanosheets (In2S3). The introduction of In2S3 is effective at improving the charge separation and transfer efficiency of Ag3PO4/In2S3, resulting in an enhancement of photoelectric behavior. The origin of the enhanced photoelectrochemical activity of the In2S3-modified Ag3PO4 may be due to the improved charge separation, photocurrent stability and oriented electrons transport pathways in environment and energy applications.

Today’s technological developments have resulted in the emergence of various new crimes threatening the international community. In recent decades, there have been various forms of cybercrimes targeted at the communication networks and defense systems of countries by other countries, known as cyber warfare. Unfortunately, international law has not specified this as a crime, but its impact has caused violations of sovereignty and disruption of national security, resulting in material loss, breakdown of communication networks and obstruction of social and public services based on the internet, such as what happened in Estonia in 2007. This article is a normative study that analyzes the elements of cybercrime relating to threats to a country’s security. The modification of the cybercrime concept is necessary to designate cybercrimes as crimes of aggression amid technological development to maintain stability in the international community.