This study attempted to reinterpret the meaning of the Roh MooHyun Jeju-Declaration in accordance with the age of artificial intelligence based on the liberal theory. In the era of artificial intelligence, a new aspect of the U.S.-China hegemonic competition was considered. The Roh MooHyun Declaration, which declared Jeju Island a peaceful island, was reinterpreted from three points of view of liberal theory. This study presented the necessity and orientation of the World Peace Island Network International Organization.

This research analyzed the environmental, social, and economic value of Jeju Island BR. The findings from this research enable us to draw the following as conclusions in relation to the value of Jeju Island BR as an internationally protected area. First: The value of BR humans can receive through conservation as an indirect use depends on two factors. One is what sectors of BR are covered in examining its value. The other is the default factor which is substituted in the estimation of an economic value by sector of the BR. Second: Sustainable use of BR refers to its direct use. It is of course true that the direct use provides humans with many benefits in terms of improving material affluence and convenience in life. Third: Sustainable use does not mean there is no impact on the conservation of BR, but it means minimal impact on the entire BR or within the resilience of natural circulating ecosystem. Fourth: In the context of the above third conclusion, it would be necessary to conduct an empirical research on whether the current land-use in BR is within its carrying capacity. Fifth: In order to achieve the land-use within the carrying capacity of BR, there must be an explicit consideration of ecological implications of the existing social and economic decision as a cultural ethos in a way to environmentalism from consumerism. Sixth: Change in human perspective on the relation between humans and nature from anthropocentrism to ecocentrism is a necessary condition to establish environmentalism as a cultural ethos. Seventh: Nonetheless, nature and human activities toward nature have been in a conflicting relationship throughout the history of human civilization. The conflicting relationship may be termed a dialectic process through historical stages.

WAIS in South Korea and WEU Inc. in Philadelphia hosting the 22nd World Peace Island Forum: Remembering Jeju King Cherry Trees Bio-diplomacy (1943) in Washington D.C. and the first Korean Congress Democracy (1919) in Philadelphia which organized by the Korean Provisional Government from March 22 to 24, 2022. We want to propose cultural historic events which connect American and Korean society, such as the Trip to Faith and Liberty Hall that relate to the integration processes of Korean and American Democracy. Dean Max Friedman of American University calls the Jeju King cherry trees cultural event bio-diplomacy among world citizens. In addition, the Korean embassy evaluated the cherry tree event as a new kind of bio-diplomacy approach which paves the way for understanding different cultures in different countries. The aim of this paper is to share present contexts and meanings about both the first Korean Congress Democracy (1919) and Bio-diplomacy (1943). We had also the 2022 GAN Korea Jeju to Philadelphia Webinar Conference: Diversity as a New Diversity for Global Ageing Network in New Normal: Jeju Village Healing, PASSi Asian Culture, Japanese Indigenous Peace Culture, and Busan Smart Health Care approach.

We have prepared MIL-101/graphene oxide (GO) composites with various mixing molar ratio of Fe-containing metal– organic frameworks (MOFs) against GO. When synthesizing MOFs, it was possible to synthesize uniform crystal powders using hydrothermal method. MIL-101 consists of a terephthalic acid (TPA) ligand, with the central metal composed of Fe, which was the working electrode material for supercapacitors. Field emission scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy, and X-ray photoelectron spectroscopy analysis had been done to ascertain microstructures and morphologies of the composites. Cyclic voltammetry, electrochemical impedance spectroscopy, and galvanostatic charge–discharge measurements were performed to analyze the electrochemical properties of the composite electrodes in 6 M KOH electrolyte. By controlling the metal ligand mole ratio against GO, we prepared a changed MOF structure and a different composite morphology, which could be studied as one of the promising optimized electrode materials for supercapacitors.

Traditional tie-dyeing is widely implemented in the clothing handicraft culture in China, South Korea, and Japan. Since it was developed 2,000 years ago, it has become a popular method of fabric making in the world and is highly respected by fashion designers. Based on the existing traditional tie-dyeing methods, this study conducted specific research on the 3D printing technology of the SLS laser method and the micro tool design application method of the clamp-dyeing process. Through the experimental methods of this study, it proposes to use the “7000 Nylon” material, which is commonly used in 3D printing, to develop a new clamp-dyeing tool. This new tool can be widely used in the clamp-dyeing of fabrics, such as cotton, hemp, silk, and some chemical fibers. The applied method and principle can be consistent with the traditional clamp-dyeing method. Therefore, the innovation of tie-dyeing technology is the best protection measure for the development and inheritance of traditional fabric making. The continuation of artistic life needs originality, which is also the best response to market competition. At the same time, this new design of the clamp-dyeing tool has the characteristics of novelty, innovation, and rich changes, which aligns with the new fashion demands of current fabric design.

This study analyzes the influence of the social and cultural background of Art Nouveau on the costumes, architecture, and crafts in the period drama ‘Crimson Peak’. This research method captures images of women’s costumes, architecture, and crafts in the ‘Crimson Peak’ and selects and analyzes those with a clear Art Nouveau influence. Edith’s costumes are characterized by the Art Nouveau style that emerged in the 1890s, with an hourglass silhouette, pastel colors, soft materials, and organic curved embellishments. Lucille’s costumes show characteristics that were prevalent before the 1890s, using bustles, strong colors, and elaborate ornamentation. The architecture is characterized by gothic vertical lines and organic curves, naturalistic patterns featuring animals and plants, and steel and glass materials. The crafts of ‘Crimson Peak’ are characterized by flexible shapes with strong, organic curves. These costumes, architecture, and crafts share formal elements including waving, twisting, and organic curves and plant-shaped motifs. The influence of social and cultural background of the age of Art Nouveau expressed in movies on formative arts was examined as impressionism appeared in costumes made of pastel colors, thin and see-through materials, medieval Gothic historicism expressed in structures composed of vertical design and religious relief ornament, exoticism appeared in Chinese vase and Japanese-patterned tea sets, naturalism with an animal plant motif and phenomenon of active social activities of progressive women through women’s clothing that elements of men’s costume are introduced. This study will provide data for the production of period dramas set at the end of the 19th century.

일상적인 화학제품들의 사용량이 증가함에 따라 사용되었던 염료 폐기물 처리 또한 중요한 환경 적인 문제로 대두되었다. 이러한 염료폐기물은 광촉매를 이용하여 분해시킬 수 있는데, 졸-겔 기술을 활용 하면 매우 비용 효율적으로 광촉매를 합성할 수 있다. 졸-겔 기술은 나노스케일의 막 형성에도 상당히 유 용하며 간단하게 다층구조를 형성할 수도 있다. 본 연구에서는 다양한 염료 분해에 효과가 있는 산화아연 (ZnO) 이용하여 다중 회전도포 방법으로 다층구조(3층, 5층)를 가진 ZnO 막을 형성하였다. 성능비교를 위해 단일 회전도포 방법에 의한 단층구조를 가진 ZnO 막을 대조군으로 준비하였다. X선 회절분석기 및 에너지 분산 X선 분광계를 이용하여 ZnO의 구조 및 원소분석을 수행하였고, 주사전자현미경을 통해 나노 선같은 표면형상을 관찰할 수 있었다. 추가적으로 UV-Vis 분광광도계를 활용하여 자외선의 흡수도를 측정 하였다. 5층구조를 가진 ZnO 막이 단층 구조를 가진 ZnO 막에 비해 모의 메틸렌 블루를 49% 더 많이 분해하였다. 결론적으로, 다층구조를 가진 ZnO 는 메틸렌블루 염료를 더욱 효과적으로 분해하는 광촉매로 써 유용하다는 알 수 있었다.

The purpose of this study is to analyze the expressive elements and techniques of graffiti appearing in the Moschino collection by Jeremy Scott. A theoretical examination of graffiti art and Moschino’s creative designer Jeremy Scott was conducted using previous studies and publications. Accordingly, keywords about the expressive elements and techniques of graffiti and Moschino were identified, as follows: expressive elements of ‘message (slogan)’, ‘symbolized letters or forms’, ‘logo and brand symbol’, ‘graffiti (scribbles)’, ‘child-like elements’, ‘daily element’s and expressive techniques of ‘using primary colors (color contrast)’, ‘deformation’, ‘distortion’, ‘exaggeration’, ‘illusion (trompe l'oeil)’, ‘collage (repetition)’, ‘simplification (flattening)’, and ‘borrowing heterogeneous objects’. These keywords were then used to analyze Moschino’s collection, comprising seven years of Moschino’s collection photographs officially recorded in the fashion magazine Vogue, ranging from the 2014 F/W to 2020 F/W collections. A total of 761 photos were initially collected, from which 561 were selected by the researcher. Expressive characteristics of graffiti in Moschino’s collection were analyzed, and identified in the following categories: ‘child-like playfulness’, ‘commercial satire’, ‘using daily elements’, and ‘borrowing non-representative techniques’. Accordingly, it was confirmed that expressive characteristics of graffiti were found in the Moschino collection by Jeremy Scott. This study anticipates the possibility of various interpretations from which fashion that communicates closely with contemporary art can be understood.

In the powder bed fusion (PBF) process, a 3D shape is formed by the continuous stacking of very fine powder layers using computer-aided design (CAD) modeling data, following which laser irradiation can be used to fuse the layers forming the desired product. In this method, the main process parameters for manufacturing the desired 3D products are laser power, laser speed, powder form, powder size, laminated thickness, and laser diameter. Stainless steel (STS) 316L exhibits excellent strength at high temperatures, and is also corrosion resistant. Due to this, it is widely used in various additive manufacturing processes, and in the production of corrosion-resistant components with complicated shapes. In this study, rectangular specimens have been manufactured using STS 316L powder via the PBF process. Further, the effect of heat treatment at 800 °C on the microstructure and hardness has been investigated.

Background: Forward head posture leads to resulting in posture instability and changes in spine alignment. To treat this condition, numerous studies have shown the effectiveness of joint mobilization. However, only a few studies have reported on the intervention location of joint mobilization or its effects on heart rate variability. Objectives: To investigated the effects of joint mobilization intervention at the lower cervical spine on pain, head posture, and heart rate variability (HRV) in patients with a forward head posture. Design: A randomized controlled trial. Methods: Twenty patients with forward head postures who met the study inclusion criteria were recruited. A randomization program was used to divide the subjects into experimental and control groups. Each group consisted of ten subjects. The intervention was performed for four weeks, three sessions per week, 15 min per day, and non-simultaneously throughout the 12-week study period. Results: A significant decrease in neck pain was shown in both the experimental and control groups. In contrast, significant changes in craniovertebral angle (CVA), cranial rotation angle (CRA), and HRV were found only in the experimental group. Conclusion: The mobilization of the cervical spine is an effective intervention for improving pain, head posture, and HRV.

Background: Volleyball is a team sport that requires a lot of movement and explosive movement. Volleyball players have different roles depending on their position. The reason is that the spiker or center is tall and the libero or setter is relatively small compared to other positions. Objectives: To investigate a difference in basic physical fitness according to the positions of volleyball players and to examine the correlation between basic physical fitness items. Design: Correlational research designs. Methods: A total of 33 male professional volleyball players were recruited for each position by position: 15 spikers, 7 centers, 5 setters, and 6 liberos. Muscle endurance, power, agility, and balance ability were measured as basic physical fitness items. Results: There was a statistically significant difference in agility according to each position (P<.05), and a positive correlation was indicated in muscle endurance and power (P<.05). Conclusion: A training program can be developed based on the correlation between training and basic physical fitness according to the positions of volleyball players.

Background: Short foot exercise, which is an intrinsic foot muscle exercise proposed by the foot core system, is used to improve the strength of intrinsic foot muscles and sensory input and function of the foot. However, there is a lack of studies that assessed the improvement in foot function after short foot exercise in patients undergoing rehabilitation after a modified Broström operation of the ankle joint. Objectives: To investigate the effects of short foot exercise on intrinsic foot muscle cross-sectional area and balance ability in patients who had undergone a modified Broström operation of the ankle joint. Design: A single blind, randomized controlled trial. Methods: Sixteen patients who were undergoing ankle rehabilitation exercises following the modified Broström operation were randomized into two groups. General physical therapy, short foot exercises, and ankle rehabilitation programs were performed in the experimental group (n=8), whereas general physical therapy and ankle rehabilitation programs were performed in the control group (n=8). For outcome measures, the intrinsic muscles of the foot were imaged using the Sonimage HS1 musculoskeletal ultrasound system. The Y-balance test and RS-foot scan system were used to confirm dynamic balance ability and static balance ability. Results: The cross-sectional area of the abductor hallucis and dynamic balance ability significantly improved in the experimental group that underwent short foot exercise compared to the control group (P<.05). In contrast, static balance ability was not significantly different between the two groups (P>.05). Conclusion: Short foot exercise successfully increased the cross-sectional area of the abductor muscle and improved dynamic balance after a modified Broström operation

Background: The circuit exercise program is a continuous method that combines complex training types and is an exercise method that is performed to improve performance by improving basic physical strength such as strength, agility, endurance and muscular endurance. Objectives: To examine the effect of exercise program on pulmonary function of professional volleyball players. Design: Randomized controlled trial. Methods: 22 professional volleyball players were divided into two groups of 11 each. A high intensity interval exercise program and circuit exercise program were performed twice a week for 45 minutes for 4 weeks. Results: The changes in pulmonary function in professional volleyball players were significantly different pre and post the intervention in both groups and the interval exercise program group showed a more significant difference before and after the intervention in Forced Expiratory Volume in 1 Second (FEV1) and Forced Expiratory Volume in 1 Second/Forced Vital Capacity (FEV1/FVC) (P<.05). In addition, there was also a significant difference in FEV1 and FEV1/FVC between two groups (P<.05). Conclusion: The interval exercise program group was effective in improving pulmonary function for professional volleyball players.

Background: Patients who underwent rotator cuff repair (RCR) require management to control pain and prevent re tear and stiffness. Thoracic mobilization has been applied for the improvement of vertebra and shoulder movements and pain reduction. Also, core stability exercise is an intervention necessary for rehabilitation after shoulder surgery. Objectives: To examine the short term benefits of thoracic mobilization and core stability exercise for patients after RCR. Design: Randomized controlled trial with multi arm parallel group and single blind assessor. Methods: 30 participants after RCR were recruited. Participants were categorized into conventional physical therapy (CPT) group, thoracic mobilization (TM) group, and core stability exercise (CSE) group according to the randomization program. Each treatment, transcutaneous electrical nerve stimuli (TENS), TM, and CSE was applied to each group. 3 physical therapists only conducted evaluations; VAS (visual analogue scale), ROM (range of motion), and Korean version of Shoulder Pain and Disability Index (SPADI). Results: VAS and SPADI were statistically reduced, and ROM was statistically improved in all 3 groups. In between three group comparisons of changes in outcome variables, there was not a significant difference in VAS, but there was a significant difference in ROM and SPADI. In the post hoc test, ROM and SPADI showed a significant difference in TM and CSE compared to CPT. Conclusion: TM according to Maitland concept and CSE had beneficial effects compared to CPT in patients after RCR.

Mesenchymal stem cells (MSCs) have been recognized as a therapeutic tool for various diseases due to its unique ability for tissue regeneration and immune regulation. However, poor survival during in vitro expansion and after being administrated in vivo limits its clinical uses. Accordingly, protocols for enhancing cell survivability is critical for establishing an efficient cell therapy is needed. CDDOMe is a synthetic C-28 methyl ester of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, which is known to stimulate nuclear factor erythroid 2-related factor 2 (Nrf2)- antioxidant response element (ARE) pathway. Herein, report that CDDO-Me promoted the proliferation of MSCs and increased colony forming units (CFU) numbers. No alteration in differentiation into tri-lineage mesodermal cells was found after CDDO-Me treatment. We observed that CDDO-Me treatment reduced the cell death induced by oxidative stress, demonstrated by the augment in the expression of Nrf2-downstream genes. Lastly, CDDO-Me led to the nuclear translocation of NRF2. Our data indicate that CDDO-Me can enhance the functionality of MSCs by stimulating cell survival and increasing viability under oxidative stress.

Lonicera caerulea (Honey berry, HB) has been used in medical treatment in Russia, Japan, China and Korea. It has high level of vitamin C and polyphenolics. Polyphenolics can improve anti-inflammatory effect and prevent cancer, diabetes mellitus type 2. Also, Vitamin C is a representative anti-oxidant. however, it is still unknown what effect it will have on the oxidation stress of the reproductive system. In previous studies, ROS can be produced when it is exposed to heat stress and has negative effect on sperm’s maturation, capacitation, hyperactivation, acrosome reaction and fusion of egg and sperm. Therefore, the purpose of this study is to investigate the antioxidant effects of L. Caerulea on the sperm and mice. At first, it conducted using ICR mouse (n = 20) for 4 weeks. There are four groups of mice (n = 5 per group). Also, L. Caerulea was taken by oral gavage. Group I (control) kept at 23℃-27℃ and administer D.W (0.5 mL/day), Likewise, Group II (HB) kept at room temperature but gave HB (250 mg/kg, 0.5 mL/day), Group III (HB + HS) received heat stress (40℃) using hyperthermia induction chamber and gave HB at same dose. and Group IV (HS) exposed heat stress only. Mainly, we showed degree of gene expression using Western blot in SOD, HSP 70, 17β-HSD and Real-time PCR. It can find correlation between intracellular activity like steroid hormone, apoptosis under ROS and antioxidant activity of L. Caerulea.

Diabetic mellitus (DM) is a carbohydrate metabolic disorder that involves high blood sugar because insulin works abnormally. Type 2 diabetes accounts for most of them. However, diabetes treatments such as GLP-1 and DPP-4 inhibitors commonly caused side effects including gastrointestinal disorders. Grifola frondosa (G. frondosa) revealed various pharmacological effects in recent studies. It has a variety of anti-cancer polysaccharides through host-mediated mechanisms. D-fraction in G. frondosa has apoptotic effects, promoting myeloid cell proliferation and differentiation into granulocytes-macrophages. It has also been shown to reduce the survival rate of breast cancer cells. Though, no further study has been conducted on the specific effects of G. frondosa in the db/db mouse. Therefore, we would like to research the blood glucose improving effect of G. frondosa, a natural material, in type 2 diabetes model mouse, in this study. G. frondosa was administered to the disease model mouse (BKS.Cg-+Leprdb/+Leprdb/OlaHsd) for 8 weeks to monitor weight and blood glucose changes every week. And we evaluated anti-diabetes effects by checking biomarker changes shown through blood. Experiment did not show statistically significant weight differences, but control groups showed significantly higher weight gain than G. frondosa administered groups. We collected blood from the tail veins of the db/db mouse each week. As a result, the lowest blood sugar level was shown in the 500 mg/ kg group of G. frondosa. Glucose in the blood was examined with HBA1c, and 7.8% was shown in the 500 mg/kg administration group, lower than in other groups. These results suggest the potential improvements of diabetes in G. frondosa.

We investigated the effect of a synthetic complement peptide C3a on the outcome of Brucella abortus 544 infection in a murine macrophage cell line RAW264.7 cell. First, we determined the highest non-cytotoxic concentration of the peptide in the cell line. We also found that the peptide significantly increased the growth of the bacteria at 8 and 24 h. Although the number of bacterial CFU was also elevated at 48 and 72 h, the increases were not significant as compared to controls. We further investigated the effect of C3a peptide on the growth of Brucella by pre-incubating the peptide at various temperatures and found that the effect was reversed at 24 h post-incubation suggesting that incubation of peptide at high temperatures including 65°C or 95°C could inactivate its action. This also could indicate the beneficial effect of high temperature during infection. Although several studies reported the inhibitory effect of different antimicrobial peptides including C3a, the present study preliminarily revealed that it had no positive contribution on the control of B. abortus 544 infection in vitro and indirectly to its receptor, CD88, which belongs to GPCR. Moreover, the encouraged further exploration of the effect of other similar peptides would be performed for the purpose of finding Brucella-host cell interaction for the control of disease progression.

This study aims to investigate the effects of exogenous succinic acid (SCA) on Brucella (B.) abortus infection in macrophage RAW 264.7 cells and ICR mice. Firstly, the in vitro experiment was conducted by MTT cytotoxicity and bacterial internalization assay to evaluate the uptake of B. abortus into macrophage cells. Two non-cytotoxic concentrations of SCA demonstrated attenuated invasion of Brucella into macrophages at 30 and 45 min post- infection (pi). Secondly, ICR mice were treated with SCA and infected with B. abortus. On day-14 pi, spleen and blood serum were collected to evaluate the bacterial burden and total spleen weight as well as the production of cytokine/chemokine, respectively. The results showed that SCA treatment promoted bacterial growth and reduced the total spleen weight in mice. Furthermore, SCA treatment increased the level of IL-10 cytokine in the sera, while dampening the production of MCP-1 chemokine compared to the control. The results of bacterial load in spleen and spleen weight together with cytokine/chemokine production profile in the sera indicated that SCA induced the host anti-inflammatory response which is beneficial for the survival of Brucella. Therefore, these findings suggest that SCA contributed to host immunity against Brucella infection and the emerging potential topic-immunometabolism should be invested for further investigations.

Patient-controlled sedation systems, in which the patient has control of sedative administration, have been shown to be effective and safe for patients undergoing minor procedures. Safety depends on the adequacy of the step-wise increase in dose of the sedative, the lockout time and patient’s ability to adjust the effective activation of the handset. While there is no patient-controlled sedation (PCS) system available domestically, we have developed a new purpose-built PCS pump, and determined its degree of precision using a microweight measuring scale. The PCS system was designed to be applied to most intravenous sedatives and work through a newly developed operating software algorithm that titrates the doses and lockout times. Our system titrates the doses through software modification, and for experimental purposes, the number of steps for handset activation by the patient was set to four, and the lockout time was set to 30 s. The degree of precision of the PCS system was tested using an electronic weighing scale. The comparison of the amount infused via the PCS system with weight on the scale showed nearly same patterns at the four infusion stages, and the difference was minimal (3% on average at each infusion step). We designed and manufactured a pilot button-type PCS pump capable of use by the patient for optimal sedation, and confirmed the precise working mechanism of the pump, thereby reducing the margin of error for infusion accuracy to 3% or less on average