In this study, freeze drying of a porous Ni with unidirectionally aligned pore channels is accomplished by using a NiO powder and camphene. Camphene slurries with NiO content of 5 and 10 vol% are prepared by mixing them with a small amount of dispersant at 50℃. Freezing of a slurry is performed at -25℃ while the growth direction of the camphene is unidirectionally controlled. Pores are generated subsequently by sublimation of the camphene during drying in air for 48 h. The green bodies are hydrogen-reduced at 400℃ and then sintered at 800℃ and 900℃ for 1 h. X-ray diffraction analysis reveals that the NiO powder is completely converted to the Ni phase without any reaction phases. The sintered samples show large pores that align parallel pores in the camphene growth direction as well as small pores in the internal walls of large pores. The size of large and small pores decreases with increasing powder content from 5 to 10 vol%. The influence of powder content on the pore structure is explained by the degree of powder rearrangement in slurry and the accumulation behavior of powders in the interdendritic spaces of solidified camphene.

Hepatic ischemia-reperfusion injury (HIRI) is linked with high mortality rate. Several agents have been developed so far to reduce the risk of HIRI. In this study, we investigated the effects of combined treatment of Ginko biloba leaves extract and vitamin C (GLEVC) on hepatic ischemia-reperfusion injury. To explore the protective effects of GLEVC on HIRI rats model were tested. After the development of HIRI by using clamping method rats were then randomly divided into four groups. Different doses of GLEVC were administered in HIRI rat model. The level of ALT, AST, SOD and MDA content in serum were detected in HIRI groups. Moreover, the activity of SOD, content of MDA, and GSH in hepatic tissue were also examined. Bcl-2 and Bax protein expression were detected by immunohistochemical staining method. Compared with sham group, GLEVC has the protective effect on the HIRI-induced model. Level of ALT, AST, and MDA in blood were significantly lower in GLEVC group compared with HIRI-induced group. Moreover, SOD activity and GSH were increased in GLEVC group whereas MDA content was reduced by GLEVC treatment. Furthermore, HIRI-induced Bax protein was reduced upon GLEVC treatment, whereas Bcl-2 protein expression was enhanced. These results demonstrate that GLEVC treatment may provide potential ameliorative therapy by reducing damaged signaling mechanism in hepatic ischemia/reperfusion injury model.

Hepatic ischemia-reperfusion injury (HIRI) is linked with high mortality rate. Several agents have been developed so far to reduce the risk of HIRI. In this study, we investigated the effects of Acanthopanax senticosus extract (AS) on hepatic ischemia-reperfusion. To explore the protective effects of A. senticosus extract injection (ASI) on hepatic ischemia-reperfusion injury rats animal model were used. After the development of HIRI by using clamping method rats were then randomly divided into five groups. Different doses of AS were administered in HIRI rat model. The level of ALT, AST, and MDA content in serum were detected in sham and HIRI groups. The activity of SOD, MPO and Ca2+-ATPase, content of MDA, and cAMP in hepatic tissue were also measured. Expression of Bcl-2 and Bax protein were detected by immunohistochemical staining method. Compared with sham group, ASI has the protective effect on the HIRI model in rats. Blood levels of ALT, AST, SOD, MPO, and MDA were significantly lower in ASI group compared with HIRI. Indeed SOD and Ca2+-ATPase activities, MDA content, and cAMP level were improved in ASI group. Furthermore, Bcl-2 and Bax protein were improved in ASI group compared with only HIRI group. These results suggest that AS may provide potential ameliorative therapy by inhibiting the damage signaling mechanism in hepatic ischemia/reperfusion injury model.

본 논문에서는 수중운동체 중 하나인 잠수함의 코닝타워(Conning tower) 위치 및 제어판 형태에 따라 4가지 타입별로 나누어 회 전팔 시험(Rotating arm test)을 실시하였다. 또한 본 RA 시험을 통하여 유체력 미계수를 추정하였으며 수평면 운동에 대한 동적 안정성 (Dynamic stability)을 평가하였다. 특히, 자유수면의 영향으로부터 자유로운 심도비(Depth ratio) 6.0에서 힘과 모멘트를 측정한 후, 다중회귀 분석을 이용하여 유체력 미계수를 추정하였다. 최종적으로 선형유체력 미계수를 이용한 수평면 동적 안정성 지수를 산정함으로써 잠수함 타 입별 특성이 동적 안정성에 미치는 영향을 분석하였다.

최근 국내외적으로 수중 유도무기체계 개발로 다양한 형태의 수중운동체 기술이 발전되고 있다. 특히 수중운동체 중 하나인 잠수함 은 한국의 특수한 상황에서 최적의 선형설계를 위한 신뢰도 높은 조종성 평가 기술이 요구되며, 이를 위한 정확한 동유체력 계수의 추정 또한 중요한 연구 분야라 할 수 있다. 따라서 본 논문에서는 잠수함 모형을 대상으로 구속모형시험인 VPMM (Vertical Planar Motion Mechanism) 시험을 실시하여 정밀도 높은 동유체력 계수를 추정하였다. 그리고 추정된 연직면 운동에 대한 선형 (Linear) 동유체력 계수 (Hydrodynamic derivatives)들을 이용하여 동안정성 (Dynamic Stability)을 판별하였다. 그 결과, 이론추정치와의 비교를 통해 동유체력 계수의 타당성이 검증 되었으며, 잠수함의 연직면 동안정성도 양호한 것으로 평가되었다. 즉, 무한수심으로 정의되는 심도 6.0의 깊은 수심으로 갈수록 주기에 따른 변화가 작아지며, 이론추정치에 근사함을 확인할 수 있었다. 한편 연직면 동안정성 판별에 있어서는, 0보다 큰 양(+)의 값을 가짐으로서 연직면 운동에 대한 동안정성을 만족하는 것으로 나타났다.

최근 들어 전 세계적으로 항공모함과 첨단 구축함 등 대규모의 최신 함정위주의 해상전력을 강화하는 상황에서 잠수함의 중요성이 더욱 부각되고 있다. 이에 따른 잠수함의 조종성능 향상을 위한 정밀한 동유체력 미계수 값이 요구된다. 본 논문에서는 VPMM(Vertical Planar Motion Mechanism) 실험을 위하여 연직 강제 동요시험(VPMM)장비를 이용하였고, 이를 통해 동유체력을 측정하였다. 심도, 주기, 속도 등을 변화시키며 다양한 환경에서 실험을 실시하였다. 잠수함 모형을 속도 U로 예인하면서 동시에 순수 상하동요(Pure heave), 순수 종동요(Pure pitch) 운동을 각각 주었고, 이때 부가되는 힘과 모멘트를 잠수함 모형의 선수·선미 부분에 장착된 로드셀을 이용하여 각각 획득하였다. 그 결 과, 푸리에 해석을 통한 잠수함 모형의 선형 유체력 미계수들을 추정할 수 있었다.

Eleutherococcus senticosus Maxim. has been successfully used as an oriental medicine for various diseases including allergic disorders. Histamine is a major factor on various allergic responses and it is reported that histamine was released from mast cells by sensitization of allergens. In this study, ethanol extracts from E. senticosus Maxim. were prepared and the composition was analyzed by high performance liquid chromatography. The eleutheroside B as a primary effective component of E. senticosus was contained approximately 225 mg/kg in root bark extracts. The extracts were found to significantly inhibit compound 48/80-induced histamine release form mast cells in dose dependent manner. However the extracts had low cytotoxicity on the mast cells with MTT assay. These results showed that E. senticosus Maxim. extracts may be the effective materials on inflammatory disorders.

Prediction of the stability for ships is very complex in reality. In this paper, risk based approach is applied to predict the probability of capsize for a certified ship, which is effected by the forces of sea especially the wave loading Safety assessment and risk analysis process are also applied for the probabilistic prediction of stability for ships. The probability of shipsencountering different waves at sea is calculated by the existed statistics data and risk based models. Finally, ship capsizing probability is calculated according to single degree of freedom(SDF) rolling differential equation and basin erosion theory of nonlinear dynamics. Calculation results show that the survival probabilities of ship excited by the forces of the seas, especially in the beam seas status, can be predicted by the risk based method.