This study examined the influence of multiple factors—particularly occupant presence and air purifier operation—on indoor PM2.5 concentrations across 104 households in the Seoul metropolitan area. Both indoor and outdoor PM2.5 concentrations were continuously monitored and integrated with time-specific survey data to analyze spatial and temporal patterns of indoor exposure. Results showed that occupant presence significantly elevated indoor PM2.5 concentrations, especially during periods of high activity (08:00~15:00 and 18:00~20:00). The indoor/outdoor (I/ O) concentration ratio was also significantly higher during these periods, indicating that occupant activities were a major contributor to indoor PM2.5 concentrations. Air purifier use was found to be associated with a consistent reduction in indoor PM2.5 concentrations, regardless of occupancy status. Notably, the I/O ratio also decreased when air purifiers were in operation, demonstrating their effectiveness in controlling both indoor emissions and the infiltration of outdoor pollutants. These findings provide empirical evidence of the multifactorial dynamics governing indoor PM2.5 exposure and highlight the importance of occupant-centered and time-specific strategies for effective residential air quality management.