In this study, a numerical analysis study was conducted on the flow characteristics according to the internal flow path change and differential pressure of the hydrogen shut-off valve, and through this, the pressure loss characteristics and flow coefficient of the hydrogen shut-off valve were predicted. ANSYS CFX program was used to predict the flow characteristics of the hydrogen shut-off valve. When the flow path gap was 1.3 mm, the design conditions of the hydrogen shut-off valve were satisfied, and the value of the flow coefficient of the valve was about 1.53. As the inlet pressure of the hydrogen shut-off valve increases, the outlet flow rate increases, but regardless of the inlet pressure, the flow coefficient of the valve is almost constant, ranging from 1.53 to 1.56, indicating that it is the inherent flow coefficient of the designed hydrogen shut-off valve.