The purpose of this study, when predicting acute oral toxicity using QSAR software, the reliability of the predicted values was studied according to a single functional group or multiple functional groups within a single chemical. Acute oral toxicity is predicted using EPA T.E.S.T S/W for chemicals registered in ChemIDplus. The effect of a combination of specific functional periods on the degree of consistency of predicted values was studied. When some specific functional groups (combinations) exist, it was confirmed that the experimental and predicted values were high and low. It was confirmed that the prediction accuracy was high when the Anion group and the Halogen group were together, and the perdiction accuracy was significantly low when the Nitrile group was present. As a result of accumulating such data and showing reliability in predicting acute oral toxicity with EPA T.E.S.T S/W for 10 SVHC substances without experimental values, the matching rate was derived from at least 0% to 73.33%. It was confirmed that there was some tendency of the QSAR prediction value according to the combination of specific complex functional groups. When 10 SVHC substances without experimental data were predicted to be toxic through T.E.S.T S/W by quantitatively databaseizing the above tendency, 0~73.33% of the results were derived as a result of showing the realiability of the program prediction

서울을 위협하는 다양한 위험요소는 재난 및 안전관리 기본법에 의하여 자연재난, 사회재난으로 구분할 수 있으며, 이외에 일상생활에서의 사고, 범죄 등을 추가할 수 있다. 최근 기후변화에 의한 예측불허한 재해발생 빈도가 증가하고 있고, 규모 또한 과거 비교할 수 없을 정도로 점점 커지고 있는 추세이다. 본 연구에서는 서울시에 발생하는 자연재난 중 풍수해에 대한 위험도 분석과 그에 따른 대책의 우선순위 결정방법에 대하여 연구하였다. 위험도 분석(발생빈도, 피해규모)을 통해 서울시 풍수해 취약성을 평가하고, 이를 통해 수립된 다양한 대책들 중 어떤 정책들을 우선적으로 시행되어야 하는지 우선순위 결정방법에 대하여 연구하였다. 본 연구를 통해 서울시의 풍수해 관련 다양한 정책들이 체계적이고 효율적으로 집행될 수 있을 것으로 판단된다.

In this study, we conducted Life-Cycle Reliability Analysis Classified by Structure Movements in Removal PSC Beam Bridge. in short, we secured experimental values of bridge design factor and perform a detailed behavior analysis of structure system. finally, we could accomplish an Life-Cycle Reliability Analysis with considering of an environmental factor and variability of loading. We defined limit state function by statistical method (Response Surface Method, RSM) and calculated confidence indicator and Probability of Failure using reliability interpretation technique(FORM). eventually, we could compute Performance Profile and compare deterioration form according to time history by structure movements.