Complex of mulberry extract (CME) is composed of extracts of mulberry (Morus alba L.) fruit, mulberryleaves and black beans (Glycine max (L.) Merr.). In this study, we investigated prevention effects of CME on degenerativearthritis. The SC50 value of DPPH radical scavenging by CME was 158.49±11.35㎍/mL. We found that CME significantlyreduced the production of nitric oxide (NO) and protein expression of cyclooxygenase-2 (COX-2) in RAW 264.7 cells whichwere activated by LPS. Experiments using animal model of degenerative arthritis showed that CME (400㎎/㎏ bodyweight) inhibited the production of TNF-α (77.5%) and IL-1β (95.0%). Furthermore, it was observed that CME reduced to85.9% of paw edema induced by carrageenan. These results suggest that CME could improve degenerative arthritis.