In actual seawater desalination plant, the pressure loss due to frictional force of pipe is about 3~5 bar. Also, the pressure loss at pipe connection about 1~3 bar. Therefore, the total pressure loss in the pipe is expected to be about 4~8 bar, which translates into 0.111 to 0.222 kWh/m3 of energy when converted into the Specific Energy Consumption(SEC). Reducing energy consumption is the most important factor in ensuring the economics of seawater desalination processes, but pressure loss in piping is often not considered in plant design. It is difficult to prevent pressure loss due to friction inside the pipe, but pressure loss at the pipe connection can be reduced by proper pipe design. In this study, seawater desalination plant piping analysis was performed using a commercial network program. The pressure loss and SEC for each case were calculated and compared by seawater desalination plant size.