Purpose: This study aims to develop a simulation module equipped with scenario-based core nursing skills and test the effects after applying the simulation education based on a developed scenario. Method: This was a nonequivalent control group pre-/posttest design study, and 114 nursing students participated from April 1 to August 30, 2018. The applied scenario-based core nursing skills simulation module was developed in the order of planning, development, application, and evaluation according to the Dick and Carye Model’s program development process. Knowledge, self-efficacy, stress, and nursing practice were measured before and after intervention in two groups: an experimental group that performed a simulation after applying the scenario-based core nursing skills, and a control group that performed a simulation after applying core nursing skills. Results: Knowledge (F=23.19, p<.001), self-efficacy (F=25.83, p<.001), and nursing practice (t=9.51 p<.001) increased in the group that performed a simulation after applying the scenario-based core nursing skills, whereas stress (F=40.41, p<.001) decreased. Conclusion: Various education methods should be applied to increase the education effect of the simulation, Simulation performance can be used as an alternative to improve nursing practice during simulation education.