In this study, high-efficiency InZnP/ZnSe/ZnS quantum dots (QDs) were synthesized and applied to the development of self-luminous traffic signs. The synthesized QDs exhibited a photoluminescence (PL) peak wavelength of 613 nm and a uniform nanoparticle size of 6 nm in diameter. Quantum dot films were coated using a roll-to-roll process with varying thicknesses (110 μm, 85 μm, and 75 μm), and color coordinate analysis confirmed that all films fell within the red region. A 4CL resin and PCB with high thermal dissipation properties were employed to fabricate the self-luminous traffic signs. Performance evaluations showed a white luminance of 625.4 cd/㎡, a red luminance of 220.2 cd/㎡, an insulation resistance of 10,000 MΩ, and an insulation breakdown voltage of 500V, indicating excellent performance. This study confirms the potential of InZnP-based QDs as an environmentally friendly alternative to conventional Cd-based QDs. Furthermore, the integration of high-efficiency QD films with advanced heat-dissipating PCB technology is expected to improve traffic safety, particularly in low-visibility and nighttime environments