As a safety device, a rupture disc are used to control pressure to minimize the explosion risk once the internal pressure of high pressure equipment exceeds a critical level. In this paper, optimization method was developed to secure optimal design of domed Rupture disks. The parameter analysis was performed through design of experiment to parameter of Rupture disk made of AISI 316.The Diameter, Thickness and Hight of Rupture disk were selected as design parameters for design parameter analysis. The results of parameter analysis revealed that the Diameter, thickness and hight were burst pressure-sensitive design parameters. Based on the valid performance factors, a regression equation to predict its performance was deducted and using the equation, an optimal design. And a sample model was fabricated, followed by burst pressure testing, after optimal design and analytical verification. In this research, it is verified that the optimal design method and the credibility of the analysis of this study is deemed very high. Furthermore, utilizing this mechanism would inspect the effect of the design parameter performance and increase the credibility and efficiency of a design.