The association between the COMT rs4680 (G>A, Val-158-Met) polymorphism and the risk of fibromyalgia has been investigated in previous studies, but the results are controversial. Therefore, a meta-analysis has been performed to confirm the association between COMT rs4680 (G>A, Val-158-Met) polymorphism and the risk of fibromyalgia in this study. Our study includes eleven case-control studies with 2,909 individuals comprised of 1,365 fibromyalgia patients and 1,544 control subjects. The regression analysis was performed using the random effects model or the fixed effects model and OR with the corresponding 95 % CI was calculated for the allele, recessive, dominant, over-dominant, co-dominant 1, and co-dominant 2 model. No statistical significant associations were observed between COMT rs4680 (G>A, Val-158-Met) polymorphism and risk of fibromyalgia in allele model (P-value = 1.00), recessive model (P-value = 1.00), dominant model (P-value = 0.54), co-dominant 1 model (P-value = 1.00) and co-dominant 2 model (P-value = 1.00). In conclusion, our meta-analysis showed that the COMT rs4680(G>A, Val-158-Met) polymorphism might not be genetic risk factor for the fibromyalgia.

Recently, with the rapid development in the industries such as mechanical plants, automobiles, ships and marine structures, it is enlarged by the use of the SS 41 steel. This mechanical plants and marine structures are exposed m corrosion because of Cl-under marine environments. To protect their accidents, mainly applied anti-corrosion epoxy coating and various protective its structures. In this study, corrosion control characteristics on the epoxy coating were investigated by the galvanic corrosion of impressed voltage tester under marine environments The main results obtained are as follows; 1. Corrosion current density of amine-epoxy coating becomes more increased than that of other epoxy coating and the time area rate of pin hole and pit until 5% becomes most rapid. 2. The potential of SUS 304 stainless steel(cathode) for Al-epoxy coating is nearly zero potential. 3. Corrosion current density of Amine-epoxy by shot blast becomes more decreased than that of not shot blast and cathodic potential becomes more noble. 4. As distance of anode and cathode is more decreased, corrosion current density of epoxy coating is more increased and cathodic potential becomes less noble.