감초에서 분리한 각각의 추출물(GHE, GME, GAE)을 BALB/c mice에 투여하여 탐식작용, 용혈 반형성, 용혈소 역가 측정 및 rosette 형성 실험을 통해 감초가 면역응답에 미치는 영향을 조사하였다. 1. 탐식능 측정에서 복강침출세포(PEC)와 비장세포(spleen cells)는 CON군에 비하여 각각의 약물투여군이 Candida parapsilosis에 대한 효과가 다소 높은 경향을 나타내었지만, 유의성은 없었다. 2. 용혈반 형성 및 용혈소 역가측정에서는 CON군에 비하여 GHE, GME 투여군 및 GAE 투여 군이 높게 나타났다. 3. Rosette형성에 대한 측정에서는 CON군에 비하여 GME, GAE 투여군이 높은 유의성을 나타내었다.

A fermented squeezed-type paste was processed in order to highly effective utilization of cockle shell by-product, and improvement on rheological properties and texture of hydrolysate by used additives. The cockle shell by-products were homogenized with addition of water and enzymatically hydrolyzed at 50℃ for 8 hours adde｀d 4% Protease N. P.(Pacific Chemical Co.). And the hydrolysate was thermally treated for the purpose of flavor improvement, enzyme inactivation and pasteurization product at 100℃ for 1 hour, with 4% glucose. To make improvement of rheological properties, used complex additive with 0.5% alginic acid, 1% pectin and 0.2% agar were very effective. And stability of mixing was 98.1% after centrifuged at 10, 000 rpm for 60 minutes. The chemical composition of moisture, total carbohydrate, total nitrogen and amino type nitrogen in the fermented squeeze-type cockle shell by-product paste were 57.7%, 20.6%, 1, 458㎎% and 1, 187㎎%, respectively. And the ratio of amino type nitrogen in total nitrogen was 81.4%.