Cold agglutinin disease (CAD) is a rare and poorly understood disorder affecting 15% of patients with autoimmune hemolytic anemia (AIHA). In this case report, we describe a case of CAD mistaken for liver cirrhosis. A 57-year-old male patient was presumptive diagnosed with early liver cirrhosis due to mild hyperbilirubinemia and abdominal sonography finding without other findings as thrombocytopenia or prothrombin time prolongation. After 3 month, the patient was referred to our hospital with agglutination of peripheral red blood cell at room temperature and livedo reticularis of the whole body and finally diagnosed with CAD associated B cell lymphoproliferative disorder.

The association between human parvovirus B19 and aplastic crisis in patients with hemolytic anemia, such as sickle-cell anemia and hereditary spherocytosis, has been well described. However, most cases of parvovirus induced-aplastic crisis in patients with hereditary spherocytosis have been reported in children or adolescents. We report on a 31-year-old female with pancytopenia who was diagnosed with aplastic crisis caused by parvovirus B19 infection in hereditary spherocytosis. It should be kept in mind that hereditary spherocytosis may initially present with aplastic crisis induced by parvovirus B19 infection in adults

JAK2 V617F mutation is a common event in chronic myeloproliferative disorders. However, de novo acute myeloid leukemia with JAK2 V617F is rarely encountered. The authors report the case of a 74-year-old male with de novo acute myeloblastic leukemia without maturation (AML M1) and a JAk2 V617F heterozygotic mutation. Despite treatment with standard AML regimens, the patient died 2 months after a diagnosis of acute leukemia. This case of an AML patient with a JAK2 V617F mutation with a poor prognosis suggests that despite its rarity, a JAK2 V617F mutational study be considered for prognostic purposes in AML.

Actinomycosis is a rare disease caused by the Gram-positive anaerobic filamentous bacterium, Actinomyces israelii. Due to its unusual clinical presentation, it is mainly diagnosed postoperatively. The risk of the disease increases with the use of intrauterine contraception device (IUD). A 46-year-old female was admitted to the hospital due to diffuse lower abdominal pain and had used an IUD until two weeks ago. Findings on abdominal computed tomography showed a large mass measuring approximately 9 cm, which was suspected of urachal cancer or omental sarcoma. After wide surgical resection, pathologic finding showed severe inflammation with sulfur granule, confirming abdominal actinomycosis.