Mucoepidermoid carcinoma (MEC) is the most prevalent malignant tumor originating from the salivary gland. The gradation of MEC is determined histologically based on cellular composition, with high-grade MEC presenting with distinct characteristics and clinical implications. A 56-year-old male presented with a 3-month history of right facial swelling and a recent onset of pain. A subsequent biopsy confirmed a malignant epithelial tumor, with further imaging assisting in determining the surgical approach. Comprehensive surgery, involving the removal of the right submandibular gland and reconstructive procedures, was undertaken. Histopathological evaluation post-surgery confirmed a high-grade MEC. The differentiation between inflammatory conditions and neoplastic lesions in the orofacial region can be challenging. The gradation of MEC is important in guiding therapeutic decisions. Among various classification systems, the Brandwein system offers detailed histopathological criteria that correlate reliably with clinical features. High-grade MECs, although less frequent, are aggressive and have a lower 5-year survival rate. Accurate histopathological diagnosis is crucial in devising an effective treatment plan. The presented case underlines the importance of a meticulous yet periodic follow-up, considering the aggressive nature of high-grade MECs.

Sarcoma is rare malignant tumors that develop from mesenchymal cells. Metastasis to the oral cavity is a rare occurrence. Undifferentiated Pleomorphic sarcoma(UPS), formerly known as Malignant fibrous histiocytoma(MFH), is rare spindle cell neoplasm that can have poorly prognosis with metastasis and local recurrence. This report describes a case of a 77-year-old man who was diagnosed with Undifferentiated Pleomorphic Sarcoma of the chest wall and underwent adjuvant radiation therapy after surgical resection. Although there was success of wide excision, two years later, he presented with metastasis to the several organs including tongue. We retrospectively analyzed results of Next Generation Sequencing(NGS), and we figured out RB1 gene mutation. Until now targeted therapy of RB1 gene mutation is not established. Surgeon needs to consider metastatic tumors through identifying patients’ chief complaints and past medical & dental history. We need to research through NGS, and take a step closer to find targeted therapy for tumors.

In this study, the MoS2 nanoparticles grown on crumpled 3D graphene microball (3D GM–MoS2) was synthesized using a microfluidic droplet generator with thermal evaporation-driven capillary compression and hydrothermal reaction. The morphology and size of 3D GM–MoS2 are controlled by the concentration of nano-sized graphene oxide (GO) and the flow rate of oil phase on the droplet generator. The 3D GM–MoS2 with fully sphere-shape and uniform size (~ 5 μm), and homogeneous growth of MoS2 nanoparticles could be synthesized at the flow rate of the oil phase of 60 μL/min with the optimized GO concentration of 1.0 mg/mL, and ( NH4)2MoS4 concentration of 2.0 mg/mL.

To develop Gastrodia elata (GE)-loaded particles for herbal extract dosage forms, various GE-loaded particles containing dextrin, isomalt, maltodextrin, and silicon dioxide as solidifying carriers in the GE water extract are prepared using the spray drying method. Their physical properties are evaluated using the repose angle, Hausner ratio, Carr's index, weight increase rate at 40oC/75% RH condition, and scanning electron microscopy (SEM). Particles made of dextrin improve the fluidity, compressibility, and water stability. In addition, 2% silicon dioxide increases the fluidity and moisture stability. The best flowability and compressibility of GE-loaded particles are observed with TP, dextrin, and silicon dioxide amounts in the ratio of 6/4/0.2 (34.29 ± 2.86°, 1.48 ± 0.03, and 38.29 ± 2.39%, repose angle, Hausner Ratio, and Carr’s index, respectively) and moisture stability with a 2% weight increase rate for 14 h at 40oC/75% RH condition. Therefore, our results suggest that the particles prepared by the spray drying method with dextrin and 2% silicon dioxide can be used as powerful particles to improve the flowability, compressibility, and moisture stability of GE.

본 연구에서는 세굴된 해저 파이프 주위 중력류의 유동 해석을 수행하였다. 결과 비교를 위해 세굴이 아닌 평평한 해저면 위에 틈새 거리를 두고 설치된 해저 파이프 문제를 함께 고려하였다. 여기서 세굴의 깊이와 틈새 거리는 동일하며, 평평한 해저면 위에 설치된 파이프 문제는 일반적으로 실제 세굴효과를 이상적으로 구현하기 위해 주로 고려된다. 중력류와 해저 파이프 상호작용에 대한 유동특성의 이해를 위해 농도 및 와도장, 압력장 그리고 양항력 계수 등, 다양한 물리량들을 비교 및 분석 하였다. 결과적으로 세굴과 평평한 해저면 위에 설치된 해저 파이프 주위 유동특성이 달라짐을 관찰하였다, 특히 세굴의 위 파이프의 경우 구조물 상부에서 발달된 음의 와만 하류로 나아가게 되지만 평탄면 위 파이프는 이열 와구조 형태를 가지는 것을 확인하였다. 따라서 중력류에 놓인 해저 파이프의 안전 설계를 위해서는 무엇보다 실제 세굴조건을 고려하는 것이 중요 할 것으로 판단된다.

The six rowed and naked barley cultivar, “Cheongho” (Hordeum vulgare L.), showing earliness, good cooking quality, resistance to powdery mildew and barley yellow mosaic virus disease (BaYMV), winter hardiness, lodging tolerance, and high yield in paddy fi